Document Detail

Effect of dexfenfluramine on sleep in healthy subjects.
MedLine Citation:
PMID:  1796129     Owner:  NLM     Status:  MEDLINE    
The acute effects of dexfenfluramine on nocturnal sleep were studied in ten healthy male subjects by means of sleep EEG recordings and ratings of subjective sleep quality. Four different dosages (3 mg, 7 mg, 15 mg, and 30 mg) were tested, administered over a period of 3 days each. Under 15 mg and 30 mg dexfenfluramine, only slight effects on sleep were observed: 15 mg led to decreased sleep efficiency in the first night of medication, and to reduced percentage of slow wave sleep in the first and third night. A significant lengthening of REM latency was present in the third night under 30 mg dexfenfluramine, without changes in other REM sleep parameters. Daily doses of 3 mg and 7 mg dexfenfluramine did not influence sleep, except for a significant REM latency reduction observed in the first night under 3 mg. Apart from a transient slight impairment under 30 mg, ratings of subjective sleep quality did not mirror any impact of dexfenfluramine. The data suggest that therapeutic dosages of dexfenfluramine only slightly influence nocturnal sleep, which contrasts with the known impact of other anti-obesity agents like the amphetamines. Unlike classical antidepressants, dexfenfluramine does not reduce REM sleep; in light of a hypothetical link between REM sleep reduction and antidepressant action of a drug, dexfenfluramine is not expected to have a pronounced antidepressant effect.
M Wiegand; S Bossert; R Kinney; K M Pirke; J C Krieg
Related Documents :
8152609 - Phasic loss of intercostal muscle activity occurring with rapid eye movements during re...
20411699 - Rivastigmine-induced rem sleep behavior disorder (rbd) in a 88-year-old man with alzhei...
1489249 - Cholinergic microstimulation of the peribrachial nucleus in the cat. ii. delayed and pr...
7173319 - Effects on sleep of phentolamine and epinephrine infused into the locus coeruleus of cats.
10771409 - Visual discrimination task improvement: a multi-step process occurring during sleep.
2016359 - Human regional cerebral blood flow during rapid-eye-movement sleep.
21045659 - Simultaneous and sequential implantation of intacs and verisyse phakic intraocular lens...
19815739 - Association between high tear epidermal growth factor levels and corneal subepithelial ...
1475569 - Self-reported sleep quality in college students: a repeated measures approach.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychopharmacology     Volume:  105     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1991  
Date Detail:
Created Date:  1992-04-07     Completed Date:  1992-04-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  213-8     Citation Subset:  IM    
Max Planck Institute of Psychiatry, München, Federal Republic of Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Dose-Response Relationship, Drug
Fenfluramine / blood,  pharmacology*
Sleep / drug effects*
Sleep, REM / drug effects
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Open field behaviours and spatial learning performance in C57BL/6 mice: early stage effects of chron...
Next Document:  Mood responses of remitted schizophrenics to methylphenidate infusion.