Document Detail


Effect of dexamethasone on glycogen deposition in pregnant rats and their fetuses.
MedLine Citation:
PMID:  4092743     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glycogen deposition was determined in pregnant rats and their fetuses twenty four hrs after maternal treatment with dexamethasone in the final days of pregnancy. Dexamethasone increases glycogen accumulation in the fetal liver, heart, adrenal glands and thymus. Simultaneously, it increases the glycogen concentration in maternal liver. In this study, dexamethasone did not change the glycogen level in the fetal kidneys, brain, placenta, lung and maternal adrenal glands. These results show that dexamethasone accelerated glycogen deposition in some fetal tissues. It is possible that dexamethasone activated enzymes of glycogen synthesis or potentiated the action of fetal corticosterone on induction of glycogen accumulation in fetal rat tissues.
Authors:
R Klepac
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental and clinical endocrinology     Volume:  86     ISSN:  0232-7384     ISO Abbreviation:  Exp. Clin. Endocrinol.     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-04-04     Completed Date:  1986-04-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302802     Medline TA:  Exp Clin Endocrinol     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  305-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenal Glands / embryology,  metabolism
Animals
Dexamethasone / pharmacology*
Female
Fetal Heart / metabolism
Fetus / metabolism*
Glycogen / metabolism*
Liver Glycogen / metabolism
Maternal-Fetal Exchange
Pregnancy
Pregnancy, Animal*
Rats
Chemical
Reg. No./Substance:
0/Liver Glycogen; 50-02-2/Dexamethasone; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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