| Effect of destruction of gyrus cinguli in rat brain on the development of tolerance to the analgesic effect of morphine and physical dependence on morphine. | |
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MedLine Citation:
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PMID: 15723131 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the effect of bilateral laser destruction of rat anterior cingulate gyrus on the analgesic effect of morphine and development of tolerance and physical dependence on morphine. Bilateral laser destruction of the anterior cingulate gyrus did not modulate pain sensitivity, analgesic effect of morphine, and development of morphine tolerance. Destruction of the cingulate gyrus alleviated symptoms of the abstinence syndrome in morphine-dependent animals. We showed that morphine-induced analgesia and morphine tolerance are not associated with activity of the anterior cingulate gyrus. However, this structure plays a key role in the development of physical dependence on morphine and abstinence syndrome. |
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Authors:
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S K Sudakov; I V Rusakova; M N Trigub; V Yu Shakhmatov; A I Kozel; G E Smith |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bulletin of experimental biology and medicine Volume: 138 ISSN: 0007-4888 ISO Abbreviation: Bull. Exp. Biol. Med. Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2005-02-21 Completed Date: 2005-06-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372557 Medline TA: Bull Exp Biol Med Country: United States |
Other Details:
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Languages: eng Pagination: 479-81 Citation Subset: IM |
Affiliation:
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National Research Center of Narcology, Russian Ministry of Health and Social Development, Moscow, Russia. s-sudakov@mtu-net.ru |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analgesia Analgesics / pharmacology* Animals Disease Models, Animal Drug Tolerance / physiology* Gyrus Cinguli / pathology, physiology* Male Morphine / pharmacology* Morphine Dependence / physiopathology* Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 57-27-2/Morphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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