Document Detail

Effect of desensitizing agents on dentin permeability.
MedLine Citation:
PMID:  19650593     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate the in vitro efficacy of two dentin desensitizing products at reducing liquid permeability through human dentin discs. The tested hypothesis was that the products, in spite of different chemical mechanisms were not different at reducing or eliminating flow through dentin discs. METHODS: Dentin slices (1 mm thick) were prepared from 16 extracted human third molars and their permeability was indirectly recorded in a split chamber model, using a chemiluminescence technique, after EDTA treatment (control), after soaking with albumin, and after desensitizer application. Two products were studied: MS Coat, a self-curing resin-containing oxalate product, and Gluma Desensitizer, a glutaraldehyde/HEMA-based agent without initiator. The dentin slices were mounted between an upper chamber, filled with an aqueous solution of 1% potassium ferricyanide and 0.3% hydrogen peroxide, and a lower chamber filled with 1% sodium hydroxide solution and 0.02% luminol. The upper solution was pressurized, and upon contact with the luminol solution a photochemical signal was generated and recorded as a measure of permeability throughout two consecutive pressurizing cycles at 2.5 and 13 kPa (26 and 133 cm H2O), respectively. RESULTS: The permeability of the control and albumin-soaked samples was similarly high. After application of the desensitizing agents, dentin permeability was reduced to virtually zero at both pressure levels (P < 0.001).
Hiroshi Ishihata; Masafumi Kanehira; Tomoko Nagai; Werner J Finger; Hidetoshi Shimauchi; Masashi Komatsu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of dentistry     Volume:  22     ISSN:  0894-8275     ISO Abbreviation:  Am J Dent     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-08-04     Completed Date:  2009-09-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806701     Medline TA:  Am J Dent     Country:  United States    
Other Details:
Languages:  eng     Pagination:  143-6     Citation Subset:  D    
Department of Restorative Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan.
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MeSH Terms
Dentin Permeability / drug effects*
Dentin Sensitivity / drug therapy*
Dentinal Fluid / physiology
Glutaral / pharmacology*
Materials Testing
Methacrylates / pharmacology*
Oxalates / pharmacology*
Reg. No./Substance:
0/Methacrylates; 0/Oxalates; 0/Pain-Free; 0/gluma desensitizer; 111-30-8/Glutaral

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