Document Detail

Effect of denervation on the synthesis of ribonucleic acid and deoxyribonucleic acid in rat diaphragm muscle.
MedLine Citation:
PMID:  5665882     Owner:  NLM     Status:  MEDLINE    
1. The effect of unilateral denervation of rat diaphragm muscle on its content of nucleic acids and their incorporation of precursors was investigated. 2. After denervation the paralysed hemidiaphragm hypertrophies and within 3 days its content of RNA increases considerably. The concentration of DNA/unit mass remains fairly constant. 3. During this period there is some increase in the rate of incorporation of [(14)C]adenine into RNA, whereas there is some diminution in the rate of incorporation of [(14)C]orotic acid. 4. Incorporation of [(14)C]adenine and [(3)H]thymidine into DNA is much increased in the paralysed tissue, reaching its maximum by about the third day, but returning to normal by the tenth. 5. The significance of these results in relation to the hypertrophy after denervation is discussed.
K L Manchester; E J Harris
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Biochemical journal     Volume:  108     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1968 Jun 
Date Detail:
Created Date:  1968-09-25     Completed Date:  1968-09-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  177-83     Citation Subset:  IM    
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MeSH Terms
Adenine / metabolism
Carbon Isotopes
DNA / biosynthesis*
DNA Replication
Diaphragm / metabolism
Hypertrophy / metabolism
Muscle Denervation*
Muscles / metabolism*
Orotic Acid / metabolism
RNA / biosynthesis*
Thymidine / metabolism
Time Factors
Reg. No./Substance:
0/Carbon Isotopes; 10028-17-8/Tritium; 50-89-5/Thymidine; 63231-63-0/RNA; 65-86-1/Orotic Acid; 73-24-5/Adenine; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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