Document Detail

Effect of dehydroleucodine on the reproductive tract of male mice.
MedLine Citation:
PMID:  21714796     Owner:  NLM     Status:  Publisher    
The effects of a sesquiterpene lactone, dehydroleucodine, on the reproductive tract were investigated using adult male mice. Dehydroleucodine was dissolved in tap water and administered as drinking water for 30 days. All the parameters were compared with a control group that received only vehicle. Animals were killed by decapitation and the trunk blood, the testes and the epididymes were collected. Plasma concentrations of testosterone and oestradiol, and testicular weight and concentration of spermatids did not change by dehydroleucodine. Nevertheless, in epididymal cauda dehydroleucodine treatment caused a diminution in sperm number, a decrease in the amount of tubular fluid and a reduction in the activity of the hydrolytic enzyme N-acetyl-β-d-glucosaminidase. However, the sperm motility was not altered by dehydroleucodine treatment, although sperm binding to zona-free oocytes increased significantly. These results suggest that dehydroleucodine, which has been implicated in the inhibition of aromatase P450, does not affect the plasma concentration of testosterone and oestradiol or testicular activity, whereas altering several epididymal parameters. The epididymis is thus a more sensitive target for dehydroleucodine action.
L Suhaiman; J Carlos de-Rosas; T Sartor; N Palmada; O S Giordano; L A Lopez
Related Documents :
23605146 - Ochratoxin a in human blood serum - retrospective long-term data.
22922806 - Growth hormone-releasing effects of whole body vibration alone or combined with squatti...
23674976 - Therapeutic effects of pre-gelatinized maca (lepidium peruvianum chacon) used as a non-...
24239956 - Plasma concentrations of saxl are associated with severe preeclampsia.
17573856 - Oxidative stress biomarkers and hormonal profile in human patients undergoing varicocel...
6437866 - Vip enhances trh-stimulated prolactin secretion of pituitary tumours. studies with 31p ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-30
Journal Detail:
Title:  Andrologia     Volume:  -     ISSN:  1439-0271     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0423506     Medline TA:  Andrologia     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 Blackwell Verlag GmbH.
Instituto de Histología y Embriología, F.C. Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Nephrotoxicity, including acquired Fanconi's syndrome, caused by adefovir dipivoxil - is there a saf...
Next Document:  Validation of reference genes in human testis and ejaculate.