Document Detail

Effect of degree of blood pressure on the hypercoagulable state in chronic atrial fibrillation.
MedLine Citation:
PMID:  11018206     Owner:  NLM     Status:  MEDLINE    
To investigate the hypothesis that higher levels of blood pressure would further promote the hypercoagulable state in atrial fibrillation (AF) by increasing the degree of hemostatic abnormalities, we studied 82 consecutive patients with chronic nonvalvular AF who were not taking antithrombotic therapy. Patients with AF had higher levels of plasma fibrin D-dimer, von Willebrand factor, and fibrinogen than controls in sinus rhythm, and no differences between tertiles of either systolic, diastolic, or mean blood pressure were found, suggesting other mechanisms may be contributing to the hypercoagulable state in AF.
F L Li-Saw-Hee; A D Blann; G Y Lip
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  86     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-11-01     Completed Date:  2000-11-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  795-7, A9     Citation Subset:  AIM; IM    
University Department of Medicine, City Hospital, Birmingham, United Kingdom.
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MeSH Terms
Atrial Fibrillation / blood,  physiopathology*
Blood Coagulation / physiology*
Blood Pressure / physiology*
Chronic Disease
Fibrin Fibrinogen Degradation Products / metabolism
Fibrinogen / metabolism
Middle Aged
Risk Factors
von Willebrand Factor / metabolism
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/fibrin fragment D; 0/von Willebrand Factor; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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