Document Detail

Effect of degeneration of the intervertebral disk on the process of diffusion.
MedLine Citation:
PMID:  9090399     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To test the hypothesis that diffusion of contrast medium into the intervertebral disk is affected by the integrity of the nucleus pulposus and annulus fibrosus.
METHODS: In canine intervertebral disks, defects were made in the annulus fibrosus and nuclear material was removed from the disk with a nucleotome. MR imaging was performed with intravenous contrast medium at 15, 30, 60, and 90 days after the procedure. The diffusion of contrast medium in the intervertebral disk was studied by visual inspection and by measuring changes in signal intensity. The intervertebral disk were classified at each MR study as normal or abnormal on the basis of the signal intensity on T2-weighted images.
RESULTS: In untreated disks after intravenous injection of contrast medium, a band of increased signal intensity was observed near the endplates that became wider with time and approached the center of the disk. In six of the 12 treated disks, the band of increased signal intensity was visibly diminished or less discrete compared with that in the control disks. Weeks later, these treated disks showed diminished signal intensity on T2-weighted images and bulging of the annulus fibrosus.
CONCLUSIONS: Intervertebral disks with defects in the annulus fibrosus and reduced cartilage content were characterized by abnormal diffusion of contrast medium into the disk, and changes characteristic of early disk degeneration were detected subsequently.
C Nguyen-minh; L Riley; K C Ho; R Xu; H An; V M Haughton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  18     ISSN:  0195-6108     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-07-07     Completed Date:  1997-07-07     Revised Date:  2013-01-14    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  435-42     Citation Subset:  IM    
Department of Radiology, Medical College of Wisconsin, Milwaukee 5322, USA.
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MeSH Terms
Contrast Media / pharmacokinetics*
Heterocyclic Compounds / pharmacokinetics*
Intervertebral Disc / pathology,  physiopathology*
Intervertebral Disc Displacement / pathology,  physiopathology*
Lumbar Vertebrae / pathology,  physiopathology
Magnetic Resonance Imaging*
Organometallic Compounds / pharmacokinetics*
Postoperative Complications / pathology,  physiopathology
Reg. No./Substance:
0/Contrast Media; 0/Heterocyclic Compounds; 0/Organometallic Compounds; 0199MV609F/gadoteridol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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