| Effect of daidzein-low-calorie diet on body weight, serum levels of glucose, resistin, and high sensitive C-reactive protein in high fat, high calorie diet induced rats. | |
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MedLine Citation:
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PMID: 22273652 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the effect of restricting calories with or without daidzein on weight, serum levels of glucose, and inflammatory markers in obese rats. METHODS: This experimental study was carried out in Jundishapur University, Ahvaz, Iran, from September 2010 to January 2011. Obesity was induced in 30 male Wistar rats (140-160, 6-8 weeks age) after 6 weeks by feeding them a high-fat diet. Then, the rats were divided into 3 groups: obese rats treated with low-calorie diet containing 50 mg/kg daidzein (n=10); obese rats treated with low-calorie diet containing dimethyl sulfoxide (n=10); and obese rats that were given ad libitum access to food as the control group (n=10). After 4 weeks, blood samples were collected in order to analyze the levels of glucose, resistin, and high sensitive C-reactive protein (CRP). RESULTS: Restriction of calories resulted in decreased blood glucose (p=0.002), and decreased levels of high sensitive CRP (p=0.000), but had no significant effect on resistin level. Daidzein administration had no significant effect on body weight, serum glucose, levels of resistin, and high sensitive CRP. CONCLUSION: Calorie restriction significantly affected body weight, serum glucose, low-grade inflammation biomarkers, and masked the effect of daidzein. |
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Authors:
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Majid Mohamad-Shahi; Majid Karandish; Fatemeh Haidari; Kosar Omidian; Seyed-Reza Fatemi-Tabatabayei; Hossein Rafiei |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Saudi medical journal Volume: 33 ISSN: 0379-5284 ISO Abbreviation: Saudi Med J Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7909441 Medline TA: Saudi Med J Country: Saudi Arabia |
Other Details:
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Languages: eng Pagination: 70-5 Citation Subset: IM |
Affiliation:
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Nutrition Research Center, Faculty of Paramedicine, Jundishapur University of Medical Sciences, Ahvaz, Iran. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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