Document Detail


Effect of the cytostatic butyric acid pro-drug, pivaloyloxymethyl butyrate, on the tumorigenicity of cancer cells.
MedLine Citation:
PMID:  9201249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previously we have shown that pivaloyloxymethyl butyrate (AN-9), a pro-drug of butyric acid (BA), is a differentiation-inducing agent in a variety of cells. In this report, we demonstrate that AN-9 is a cytostatic but not cytotoxic agent in a myelomonocytic cell line (WEHI); thus, the cells were growth-arrested and differentiated. These late changes in the cells were preceded by changes in the expression of the early regulatory genes, c-myc and c-jun. Although initiation of all these events had already occurred after 1 h exposure to AN-9, the tumorigenicity of these cells tested in Balb/c mice was not affected. A marked reduction in the tumorigenicity of AN-9-treated cells was observed after 4 h of exposure. Exposure of the highly metastatic subclone of Lewis lung carcinoma (3LLD122) to AN-9 resulted in a very pronounced effect on the tumorigenicity of these cells tested in C57BL mice. Unlike WEHI cells, the tumorigenicity of 3LLD122 was almost completely diminished after 1 h of exposure. In both cell types a 10-fold higher concentration of BA did not affect the tumorigenicity of the cells as did AN-9.
Authors:
A Aviram; A Rephaeli; M Shaklai; A Nudelman; I Ben-Dror; L Maron; E Rabizadeh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cancer research and clinical oncology     Volume:  123     ISSN:  0171-5216     ISO Abbreviation:  J. Cancer Res. Clin. Oncol.     Publication Date:  1997  
Date Detail:
Created Date:  1997-07-10     Completed Date:  1997-07-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902060     Medline TA:  J Cancer Res Clin Oncol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  267-71     Citation Subset:  IM    
Affiliation:
Institute of Hematology, Rabin Medical Center, Tel Aviv University, Israel.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents / pharmacology*
Butyrates / pharmacology*
Carcinoma, Lewis Lung / drug therapy*
Gene Expression Regulation, Neoplastic / drug effects*
Genes, jun / drug effects
Genes, myc / drug effects
Leukemia, Myelomonocytic, Acute / drug therapy*
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
RNA, Neoplasm / drug effects
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Butyrates; 0/RNA, Neoplasm; 122110-53-6/pivalyloxymethyl butyrate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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