| Effect of cyclooxygenase inhibition on amphotericin B-induced lung injury in awake sheep. | |
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MedLine Citation:
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PMID: 1607684 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Amphotericin therapy in humans has been reported to cause severe pulmonary dysfunction in some patients, and these abnormalities have been reproduced in unanesthetized sheep. To determine the role of cyclooxygenase products in this response, paired, random-order experiments in 11 sheep were done using the cyclooxygenase inhibitor ibuprofen. Ibuprofen blunted increases in pulmonary artery pressure (Ppa) after amphotericin (peak Ppa 38 +/- 3 cm H2O in amphotericin-alone group vs. 30 +/- 1 cm H2O in ibuprofen + amphotericin group, P less than .05) and reduced peak lung lymph flow to approximately 170% of baseline compared with 350% of baseline in amphotericin-alone group (P less than .05). In addition, the increase in airflow resistance across the lung and the decrease in partial pressure of oxygen seen after amphotericin was blocked by ibuprofen. Therefore, amphotericin-induced lung dysfunction is produced in part through the generation of cyclooxygenase products of arachidonic acid metabolism and can be ameliorated by pretreatment with the cyclooxygenase inhibitor ibuprofen. |
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Authors:
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W D Hardie; A P Wheeler; P W Wright; B B Swindell; G R Bernard |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 166 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 1992 Jul |
Date Detail:
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Created Date: 1992-07-20 Completed Date: 1992-07-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 134-8 Citation Subset: AIM; IM |
Affiliation:
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Vanderbilt University, Nashville, Tennessee. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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6-Ketoprostaglandin F1 alpha
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analysis Amphotericin B / administration & dosage, antagonists & inhibitors, toxicity* Animals Body Temperature / drug effects Ibuprofen / administration & dosage, pharmacology* Infusions, Intravenous Leukocyte Count Lung / drug effects* Lung Compliance / drug effects Pulmonary Ventilation / drug effects Pulmonary Wedge Pressure / drug effects Sheep Thromboxane B2 / analysis |
| Grant Support | |
ID/Acronym/Agency:
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HL-07123/HL/NHLBI NIH HHS; HL-19153/HL/NHLBI NIH HHS; RR-05424/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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1397-89-3/Amphotericin B; 15687-27-1/Ibuprofen; 54397-85-2/Thromboxane B2; 58962-34-8/6-Ketoprostaglandin F1 alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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