Document Detail

Effect of cyclooxygenase-2 inhibitors on blood pressure.
MedLine Citation:
PMID:  12639178     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the effect of cyclooxygenase-2 selective inhibitors (CSIs) on blood pressure. DATA SOURCES: Clinical literature accessed through MEDLINE (1966-May 2002). Key search terms included COX-2 selective inhibitors; anti-inflammatory agents, nonsteroidal; celecoxib; rofecoxib; and hypertension. DATA SYNTHESIS: Data from prospective studies on the effects of CSIs on blood pressure are conflicting. Several studies have reported increased blood pressure as an adverse effect of CSIs. CONCLUSIONS: Additional studies are needed to evaluate the effects of CSIs on blood pressure. CSIs should be used with caution in hypertensive patients and blood pressure monitored closely if a CSI is indicated.
Deanna L Johnson; Tina M Hisel; Beth Bryles Phillips
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Annals of pharmacotherapy     Volume:  37     ISSN:  1060-0280     ISO Abbreviation:  Ann Pharmacother     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-17     Completed Date:  2003-06-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9203131     Medline TA:  Ann Pharmacother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  442-6     Citation Subset:  IM    
University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*,  therapeutic use
Blood Pressure / drug effects*
Cyclooxygenase 2
Cyclooxygenase 2 Inhibitors
Cyclooxygenase Inhibitors / pharmacology*,  therapeutic use
Hypertension / drug therapy
Isoenzymes / antagonists & inhibitors
Lactones / pharmacology,  therapeutic use
Membrane Proteins
Prostaglandin-Endoperoxide Synthases
Randomized Controlled Trials as Topic
Sulfonamides / pharmacology,  therapeutic use
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Cyclooxygenase 2 Inhibitors; 0/Cyclooxygenase Inhibitors; 0/Isoenzymes; 0/Lactones; 0/Membrane Proteins; 0/Pyrazoles; 0/Sulfonamides; 0/Sulfones; 0/rofecoxib; 169590-42-5/celecoxib; EC 2; EC protein, human; EC Synthases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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