| Effect of cutaneously applied nonionic surfactants and local anesthetic bases on thermal sensations. | |
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MedLine Citation:
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PMID: 14964422 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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With cutaneously applied local anesthetic bases various effects may be observed, such as a decrease in pricking pain and a change in burning, itch, and thermal sensations. These effects occur after skin penetration and may be attributed to the action of the anesthetics on nociceptors and thermoreceptors, i.e., on C and A delta nerve fibers, respectively. As little is known about the pharmacodynamic response of nonionic surfactants with a potentially anesthetic action such as polidocanol, this study characterizes nonionic surfactants pharmacodynamically by measuring thermal thresholds with a thermal sensory analyzer after cutaneous application. The results obtained with the nonionic surfactants were compared with data resulting from the cutaneous application of local anesthetic bases such as mepivacaine, bupivacaine, prilocaine, lidocaine, the 1:1 mixture of lidocaine and prilocaine contained in EMLA and a triple mixture consisting of lidocaine, prilocaine and tetracaine (1:1:1). The results show that none of the investigated surfactants affect thermal thresholds probably due to their high molecular weight. The same was observed with the anesthetics mepivacaine and bupivacaine. In contrast, prilocaine, lidocaine, the 1:1 mixture of lidocaine and prilocaine and the triple mixture consisting of lidocaine, prilocaine and tetracaine (1:1:1) proved to be potent local anesthetics. However, their pharmacodynamic responses do not differ significantly from each other. |
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Authors:
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C S Leopold; H I Maibach |
Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Die Pharmazie Volume: 59 ISSN: 0031-7144 ISO Abbreviation: Pharmazie Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2004-02-13 Completed Date: 2004-03-08 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9800766 Medline TA: Pharmazie Country: Germany |
Other Details:
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Languages: eng Pagination: 50-4 Citation Subset: IM |
Affiliation:
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Department of Dermatology, School of Medicine, University of California, San Francisco, CA, USA. cleopold@rz.uni-leipzig.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adult Aged Anesthetics, Local / administration & dosage, pharmacology* Cold Temperature Drug Combinations Female Hot Temperature* Humans Lidocaine / administration & dosage, pharmacology Male Mepivacaine / administration & dosage, pharmacology Middle Aged Perception / drug effects* Prilocaine / administration & dosage, pharmacology Surface-Active Agents / administration & dosage, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Local; 0/Drug Combinations; 0/EMLA; 0/Surface-Active Agents; 137-58-6/Lidocaine; 721-50-6/Prilocaine; 96-88-8/Mepivacaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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