Document Detail

Effect of crude saponin of Korean red ginseng on high-fat diet-induced obesity in the rat.
MedLine Citation:
PMID:  15655288     Owner:  NLM     Status:  MEDLINE    
The anti-obesity effects of crude saponin (CS) of Korean red ginseng (KRG) were investigated in the rat fed a high-fat (HF) diet. Male Sprague-Dawley (SD) rats became obese by feeding the HF diet over 5 weeks, while the control rats were fed a normal diet, and then both groups were treated with CS (200 mg/kg, i.p.) for 3 weeks. The body weight, food consumption, adipose tissues, and expression of appetite peptides such as leptin and neuropeptide Y (NPY) were investigated in rats fed normal and HF diet after treatment of CS. Administration of CS reduced body weight, food intake, and fat content in HF diet rats in a manner similar to those of the normal diet fed rats. The hypothalamic NPY expression and serum leptin level were reduced in HF diet rats after CS treatment. Our results suggest that CS may be useful in the treatment of obesity and related disorders as anti-obesity agents.
Ji Hyun Kim; Dae Hyun Hahm; Deck Chun Yang; Jang Hyun Kim; Hye Jung Lee; Insop Shim
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-01-15
Journal Detail:
Title:  Journal of pharmacological sciences     Volume:  97     ISSN:  1347-8613     ISO Abbreviation:  J. Pharmacol. Sci.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-24     Completed Date:  2005-12-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101167001     Medline TA:  J Pharmacol Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  124-31     Citation Subset:  IM    
Department of Oriental Medical Science, Graduate School of East-West Medical Science, Kyung Hee University, Korea.
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MeSH Terms
Adipose Tissue / drug effects,  physiology
Body Weight / drug effects,  physiology
Dietary Fats / administration & dosage,  adverse effects*
Disease Models, Animal
Drug Administration Schedule
Eating / drug effects,  physiology
Gene Expression / drug effects,  physiology
Hypothalamus / drug effects,  metabolism,  ultrastructure
Injections, Intraperitoneal
Leptin / blood,  genetics
Neuropeptide Y / genetics,  metabolism,  pharmacology
Obesity / blood,  chemically induced,  physiopathology*
Panax / chemistry*
Plants, Medicinal / chemistry
Rats, Sprague-Dawley
Saponins / chemistry,  pharmacology,  therapeutic use*
Time Factors
Reg. No./Substance:
0/Dietary Fats; 0/Leptin; 0/Neuropeptide Y; 0/Saponins

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