Document Detail

Effect of creatine loading on neuromuscular fatigue threshold.
MedLine Citation:
PMID:  10642369     Owner:  NLM     Status:  MEDLINE    
The purpose of this investigation was to determine the effect of creatine (Cr) loading on the onset of neuromuscular fatigue by monitoring electromyographic fatigue curves from the vastus lateralis muscle using the physical working capacity at the fatigue threshold (PWC(FT)) test. Using a double-blind random design, 15 women athletes [mean age 19.0 +/- 2.0 (SD) yr] from the university crew team received a placebo (n = 8; 20 g glucose) or Cr (n = 7; 5 g Cr monohydrate + 20 g glucose) four times per day for 5 consecutive days. Analysis of covariance was used to analyze the data (covaried for presupplementation PWC(FT) values). The adjusted mean postsupplementation PWC(FT) value for the Cr group (mean = 186 W) was significantly (P < 0.05) higher than that of the placebo group (mean = 155 W). These findings suggest that Cr loading may delay the onset of neuromuscular fatigue.
J Stout; J Eckerson; K Ebersole; G Moore; S Perry; T Housh; A Bull; J Cramer; A Batheja
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  88     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2000 Jan 
Date Detail:
Created Date:  2000-03-28     Completed Date:  2000-03-28     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  109-12     Citation Subset:  IM    
Exercise Science Department, Creighton University, Omaha, Nebraska 68178, USA.
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MeSH Terms
Analysis of Variance
Body Height
Body Weight
Creatine / administration & dosage,  pharmacology*
Dietary Supplements
Double-Blind Method
Muscle Fatigue / drug effects*,  physiology
Muscle, Skeletal / drug effects*,  physiology
Neuromuscular Junction / drug effects*,  physiology
Random Allocation
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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