Document Detail


Effect of cow's milk exposure and maternal type 1 diabetes on cellular and humoral immunization to dietary insulin in infants at genetic risk for type 1 diabetes. Finnish Trial to Reduce IDDM in the Genetically at Risk Study Group.
MedLine Citation:
PMID:  11016449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Type 1 diabetes is considered to be a T-cell-mediated autoimmune disease in which insulin-producing beta-cells are destroyed. Immunity to insulin has been suggested to be one of the primary autoimmune mechanisms leading to islet cell destruction. We have previously shown that the first immunization to insulin occurs by exposure to bovine insulin (BI) in cow's milk (CM) formula. In this study, we analyzed the development of insulin-specific T-cell responses by proliferation test, emergence of insulin-binding antibodies by enzyme immunoassay, and insulin autoantibodies by radioimmunoassay in relation to CM exposure and family history of type 1 diabetes in infants with a first-degree relative with type 1 diabetes and increased genetic risk for the disease. The infants were randomized to receive either an adapted CM-based formula or a hydrolyzed casein (HC)-based formula after breast-feeding for the first 6-8 months of life. At the age of 3 months, both cellular and humoral responses to BI were higher in infants exposed to CM formula than in infants fully breast-fed (P = 0.015 and P = 0.007). IgG antibodies to BI were higher in infants who received CM formula than in infants who received HC formula at 3 months of age (P = 0.01), but no difference in T-cell responses was seen between the groups. T-cell responses to BI at 9 months of age (P = 0.05) and to human insulin at 12 (P = 0.014) and 24 months of age (P = 0.009) as well as IgG antibodies to BI at 24 months of age (P = 0.05) were lower in children with a diabetic mother than in children with a diabetic father or a sibling, suggesting possible tolerization to insulin by maternal insulin therapy. The priming of insulin-specific humoral and T-cell immunity occurs in early infancy by dietary insulin, and this phenomenon is influenced by maternal type 1 diabetes.
Authors:
J Paronen; M Knip; E Savilahti; S M Virtanen; J Ilonen; H K Akerblom; O Vaarala
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diabetes     Volume:  49     ISSN:  0012-1797     ISO Abbreviation:  Diabetes     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-10-17     Completed Date:  2000-10-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372763     Medline TA:  Diabetes     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1657-65     Citation Subset:  AIM; IM    
Affiliation:
Hospital for Children and Adolescents, University of Helsinki, Finland. johanna.paronen@hus.fi
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibody Formation
Autoantibodies / blood
Autoimmunity
Caseins
Cattle
Diabetes Mellitus, Type 1 / genetics,  immunology*
Diet*
Female
Genetic Predisposition to Disease*
Humans
Immunity, Cellular
Immunization*
Immunoenzyme Techniques
Infant
Infant Food
Insulin / administration & dosage,  immunology*
Milk*
T-Lymphocytes / immunology
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Caseins; 11061-68-0/Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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