Document Detail

Effect of cortisol on C-type natriuretic Peptide in ovine pregnancy: differential responses in fetal and placental tissues.
MedLine Citation:
PMID:  20802376     Owner:  NLM     Status:  In-Data-Review    
We have used aminoterminal pro C-type natriuretic peptide (NTproCNP)-a stable marker of CNP secretion-to study the effect of cortisol on CNP secretion and fetal growth. In ovine pregnancy, maternal plasma NTproCNP (largely sourced from the placenta) increases at the end of the first trimester and then decreases abruptly preterm during the phase of fetal surge in cortisol secretion. Postulating that increases in cortisol, as occurs in the fetal or maternal circulation in late pregnancy, will reduce CNP secretion, we studied the fetal and maternal responses in NTproCNP to sustained low-dose infusions of cortisol (1.2 mg/d/kg for 11 d) delivered to the fetus from d 117 gestation. Fetal plasma NTproCNP was progressively reduced during fetal cortisol infusions, whereas fetal girth growth was unchanged. In contrast, maternal NTproCNP was unaffected by cortisol. We conclude that fetal but not placental tissue production of CNP is reduced by small increments in fetal cortisol. Failure to reduce maternal NTproCNP may relate to the continuing presence of the placental barrier to cortisol at this stage of pregnancy. ABBREVIATIONS::
Timothy C R Prickett; Bryony A McNeill; Mark H Oliver; Jane E Harding; Eric A Espiner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  68     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-07-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  462-5     Citation Subset:  IM    
Department of Medicine [T.C.R.P., E.A.E.], University of Otago, Christchurch 8015, New Zealand; Agriculture and Life Sciences Division [B.A.M.], Lincoln University, Lincoln 7647, New Zealand; The Liggins Institute [M.H.O., J.E.H.], The University of Auckland, Private Bag 92019, Auckland 1023, New Zealand.
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