| Effect of coronary occlusion site on ischaemic bed size and collateral blood flow in dogs. | |
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MedLine Citation:
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PMID: 7326685 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ischaemic bed size (myocardium at risk) and collateral flow are major determinants of experimental myocardial infarct size. These parameters were compared in dogs with coronary occlusions at four commonly used sites. Regional blood flow was measured 5 min after proximal coronary occlusion of the circumflex (LCC) or anterior descending (LAD) arteries, or after distal occlusion of the LAD, or its apical branch. Occlusions were done sequentially in random order separated by 30 min intervals. The anatomic regions normally supplied by each occluded artery (ischaemic beds) were identified by simultaneous postmortem coronary perfusion with different coloured dyes. Proximal occlusions of the LCC and LAD produced equivalent areas of ischaemia (37 and 36% of the left ventricle) and these ischaemic beds had similar amounts of collateral flow (0.12 and 0.16 cm3.min-1.g-1). In comparison, distal LAD and apical branch occlusions involved 23 and 11% of the LV and collateral flow averaged 0.23 and 0.36 cm3.min-1.g-1. Thus, proximal LAD or LCC occlusion produce comparable areas of severe ischaemia. Experimental models using distal occlusions are characterised by more variable but often less severe ischaemia. |
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Authors:
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K A Reimer; R E Ideker; R B Jennings |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cardiovascular research Volume: 15 ISSN: 0008-6363 ISO Abbreviation: Cardiovasc. Res. Publication Date: 1981 Nov |
Date Detail:
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Created Date: 1982-04-20 Completed Date: 1982-04-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 668-74 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Collateral Circulation Constriction Coronary Circulation* Coronary Disease / physiopathology* Coronary Vessels / physiopathology Disease Models, Animal Dogs Heart Ventricles / physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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HL00546/HL/NHLBI NIH HHS; HL23138/HL/NHLBI NIH HHS; HV-52999/HV/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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