| Effect of coronary artery size on the prevalence of atherosclerosis. | |
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MedLine Citation:
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PMID: 8857475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the effect of coronary artery size on the prevalence of atherosclerosis, we measured the diameters of the major coronary arteries prospectively in 884 consecutive patients referred for coronary arteriography. For each artery, we assigned patients to 3 groups: group S (small) and group L (large) with diameters >1SD smaller and larger, respectively, than the mean; and group A (average), with diameters within 1SD of the mean. As specified during study design, we compared the frequency of lesions > or = 50% diameter stenosis in groups S and L for each artery. We adjusted for relevant covariates by performing logistic regression on data from all 884 patients with coronary diameter entered as a continuous variable. In group S versus L, respectively, the frequency of > or = 50% lesion was 6.5% versus 2.4% (p = 0.13) in the left main artery; 61.3% versus 35.8% (p = 0.0001) in the right coronary artery; 58.1% versus 40.7% (p = 0.008) in the left anterior descending artery, and 47.4% versus 22.2% (p = 0.0001) in the circumflex artery. Multivariate analysis showed that coronary diameter was a significant independent predictor of lesions in the right coronary artery (p = 0.000001), left anterior descending artery (p = 0.001), and circumflex artery (p = 0.0002) and nearly significant in the left main artery (p = 0.077). Thus, small coronary artery size may be a risk factor for atherosclerosis. |
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Authors:
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O N Nwasokwa; M Weiss; C Gladstone; M M Bodenheimer |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: The American journal of cardiology Volume: 78 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1996 Oct |
Date Detail:
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Created Date: 1996-11-27 Completed Date: 1996-11-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 741-6 Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiology, Harris Chasanoff Heart Institute, Long Island Jewish Medical Center, New Hyde Park, New York, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Chi-Square Distribution Coronary Angiography* Coronary Artery Disease / epidemiology*, radiography Coronary Disease / radiography* Female Humans Male Middle Aged Multivariate Analysis Prevalence Prospective Studies Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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