Document Detail

Effect of cordycepin (3'-deoxyadenosine) on hematogenic lung metastatic model mice.
MedLine Citation:
PMID:  15796166     Owner:  NLM     Status:  MEDLINE    
We investigated the anti-metastatic effect of cordycepin (3'-deoxyadenosine) on a hematogenic metastatic mouse model which was intravenously injected with B16-BL6 melanoma cells. A 3-hour exposure to various concentrations of cordycepin (0.3, 1 and 3 microg/ml) dose-dependently reduced the number of nodules formed in lung at 15 days after the tumor injection. To elucidate the mechanism of this anti-metastatic effect, we examined the effect of cordycepin on the invasiveness of B16-BL6 cells using a chemo-invasion chamber in vitro. The B16-BL6 cells pretreated with cordycepin (3 microg/ml) for 3 hours showed a significant decrease in invasiveness. Under the same conditions, however, cordycepin did not influence the growth curve of B16-BL6 cells at concentrations up to 3 microg/ml. These results suggest that cordycepin exerts an anti-metastatic action, in part, by inhibiting the invasiveness of mouse melanoma cells.
Kazuki Nakamura; Keiko Konoha; Noriko Yoshikawa; Yu Yamaguchi; Satomi Kagota; Kazumasa Shinozuka; Masaru Kunitomo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  19     ISSN:  0258-851X     ISO Abbreviation:  In Vivo     Publication Date:    2005 Jan-Feb
Date Detail:
Created Date:  2005-03-30     Completed Date:  2005-08-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  137-41     Citation Subset:  IM    
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Hyogo 663-8179, Japan.
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MeSH Terms
Antineoplastic Agents / pharmacology*
Deoxyadenosines / pharmacology*
Disease Models, Animal*
Dose-Response Relationship, Drug
Injections, Intravenous
Lung Neoplasms / prevention & control*,  secondary*
Melanoma, Experimental / pathology
Mice, Inbred C57BL
Neoplasm Invasiveness / prevention & control
Neoplasm Metastasis / prevention & control*
Neoplasm Transplantation
Specific Pathogen-Free Organisms
Time Factors
Tumor Cells, Cultured
Reg. No./Substance:
0/Antineoplastic Agents; 0/Deoxyadenosines; 73-03-0/cordycepin

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