| Effect of copper and iron ions on cytotoxicity induced by ascorbate, gallate and caffeate. | |
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MedLine Citation:
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PMID: 9216684 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Four antioxidants, sodium ascorbate, gallic acid, n-propyl gallate and caffeic acid, induced apoptotic cell death in human promyelocytic leukemic HL-60 cells. The effects of all these compounds were enhanced by CuCl2 or deferoxamine mesylate, an iron chelator, but were reduced by FeCl3. ESR spectroscopy showed that both CuCl2 and FeCl3 enhanced the ascorbyl radical intensity, but reduced the gallate and caffeate radical intensity. The present data demonstrate that copper and iron ions modify the cytotoxic activity of these antioxidants differently and their radical intensity is not the sole determinant of cytotoxic activity. |
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Authors:
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K Satoh; H Sakagami |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anticancer research Volume: 17 ISSN: 0250-7005 ISO Abbreviation: Anticancer Res. Publication Date: 1997 May-Jun |
Date Detail:
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Created Date: 1997-08-04 Completed Date: 1997-08-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: GREECE |
Other Details:
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Languages: eng Pagination: 2181-4 Citation Subset: IM |
Affiliation:
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Analysis Center, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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toxicity* Antioxidants / toxicity* Apoptosis / drug effects Ascorbic Acid / toxicity* Caffeic Acids / toxicity* Cell Survival / drug effects* Copper / pharmacology* Deferoxamine / toxicity Drug Synergism Electron Spin Resonance Spectroscopy Ferric Compounds / pharmacology* Gallic Acid / toxicity* HL-60 Cells / drug effects* Humans Kinetics Propyl Gallate / toxicity |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Antioxidants; 0/Caffeic Acids; 0/Ferric Compounds; 121-79-9/Propyl Gallate; 149-91-7/Gallic Acid; 331-39-5/caffeic acid; 50-81-7/Ascorbic Acid; 70-51-9/Deferoxamine; 7440-50-8/Copper; 7447-39-4/cupric chloride; 7705-08-0/ferric chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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