Document Detail


Effect of copper and iron ions on cytotoxicity induced by ascorbate, gallate and caffeate.
MedLine Citation:
PMID:  9216684     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Four antioxidants, sodium ascorbate, gallic acid, n-propyl gallate and caffeic acid, induced apoptotic cell death in human promyelocytic leukemic HL-60 cells. The effects of all these compounds were enhanced by CuCl2 or deferoxamine mesylate, an iron chelator, but were reduced by FeCl3. ESR spectroscopy showed that both CuCl2 and FeCl3 enhanced the ascorbyl radical intensity, but reduced the gallate and caffeate radical intensity. The present data demonstrate that copper and iron ions modify the cytotoxic activity of these antioxidants differently and their radical intensity is not the sole determinant of cytotoxic activity.
Authors:
K Satoh; H Sakagami
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  17     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1997 May-Jun
Date Detail:
Created Date:  1997-08-04     Completed Date:  1997-08-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  2181-4     Citation Subset:  IM    
Affiliation:
Analysis Center, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / toxicity*
Antioxidants / toxicity*
Apoptosis / drug effects
Ascorbic Acid / toxicity*
Caffeic Acids / toxicity*
Cell Survival / drug effects*
Copper / pharmacology*
Deferoxamine / toxicity
Drug Synergism
Electron Spin Resonance Spectroscopy
Ferric Compounds / pharmacology*
Gallic Acid / toxicity*
HL-60 Cells / drug effects*
Humans
Kinetics
Propyl Gallate / toxicity
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Antioxidants; 0/Caffeic Acids; 0/Ferric Compounds; 121-79-9/Propyl Gallate; 149-91-7/Gallic Acid; 331-39-5/caffeic acid; 50-81-7/Ascorbic Acid; 70-51-9/Deferoxamine; 7440-50-8/Copper; 7447-39-4/cupric chloride; 7705-08-0/ferric chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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