| Effect of copper on antioxidant ability and nutrient metabolism in broiler chickens stimulated by lipopolysaccharides. | |
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MedLine Citation:
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PMID: 22164958 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The aim of the experiment was to investigate the interaction between Cu intake, inflammatory challenge and oxidative stress in broiler chickens. Furthermore, it was tested whether plasma ceruloplasmin (Cp) could be a sensible parameter for dietary Cu. One hundred forty-four day old chickens were raised on a basal control diet without added copper (Group Cu-6.5, basal Cu content 6.5 mg/kg diet) or a diet supplemented with Cu at 8 or 50 mg/kg (Groups Cu-14.5 and Cu-56.5, respectively) with four replicates of 12 animals for each treatment. Starting on day 21, chickens were injected intraperitoneally with lipopolysaccharides (LPS) once a day for 3 days. Before this challenge, Group Cu-14.5 had the lowest gain and the feed to gain ratio was the highest. After injection of LPS, however, chickens of Group Cu-14.5 had the best zoo-technical performance. For chickens of Group Cu-6.5, LPS injection resulted in elevated rectal temperature, and lower erythrocyte superoxide dismutase (CuZn-SOD) activity, compared with the other groups. LPS injection increased plasma uric acid in Group Cu-6.5 significantly, but was without influence in Group Cu-56.5. At all Cu-levels, LPS injection increased erythrocyte CuZn-SOD activity and decreased thiobarbituric acid reacting substances. No significant difference in plasma Cp was found in chickens fed different dietary Cu. LPS injection significantly increased plasma Cp in Group Cu-56.5. The results suggest that varying dietary Cu levels seem to modulate the parameters involved in immunological responses and oxidant stress and that plasma Cp is not a reliable parameter for dietary Cu. |
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Authors:
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Zhigang Song; Tong Zhao; Lei Liu; Hongchao Jiao; Hai Lin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of animal nutrition Volume: 65 ISSN: 1745-039X ISO Abbreviation: Arch Anim Nutr Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-12-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101222433 Medline TA: Arch Anim Nutr Country: England |
Other Details:
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Languages: eng Pagination: 366-75 Citation Subset: IM |
Affiliation:
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Department of Animal Science, Shandong Agricultural University, Taian, Shandong, P.R. China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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