| Effect of cooling on supraoptic neurohypophysial neuronal activity and on urine flow in the rat. | |
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MedLine Citation:
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PMID: 6747884 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The activity of antidromically identified supraoptic neurosecretory neurones was recorded in Sprague-Dawley rats under urethane or sodium pentobarbitone anaesthesia during cooling of the body with a cold pack. Of twelve phasic neurones studied during a complete cooling and rewarming cycle, six displayed an initial increase, followed by a depression in activity during the period of reduced body temperature. The remaining six phasic neurones did not alter their activity during cooling. Non-phasic neurohypophysial neurones displayed a reversible reduction (n = 8), or increase (n = 6) in activity during cooling, while seven neurones were unaffected by changes in body temperature. In four other anaesthetized Sprague-Dawley rats, urine flow was reduced by approximately 50% during cooling; this was followed by a diuresis after removal of the cold pack and return of body temperature to normal. The antidiuresis did not occur in homozygous Brattleboro rats which lack arginine vasopressin. The electrophysiological data from a proportion of the supraoptic neurohypophysial neurones correlate with the observed changes in urine flow. |
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Authors:
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A V Ferguson; Q J Pittman; C L Riphagen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of physiology Volume: 352 ISSN: 0022-3751 ISO Abbreviation: J. Physiol. (Lond.) Publication Date: 1984 Jul |
Date Detail:
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Created Date: 1984-09-19 Completed Date: 1984-09-19 Revised Date: 2010-09-10 |
Medline Journal Info:
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Nlm Unique ID: 0266262 Medline TA: J Physiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 103-12 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials Animals Blood Pressure Cold Temperature* Diuresis* Male Neurons / physiology* Osmolar Concentration Pituitary Gland, Posterior / physiology Rats Rats, Brattleboro Rats, Inbred Strains Supraoptic Nucleus / physiology* Time Factors Urine Vasopressins / physiology |
| Chemical | |
Reg. No./Substance:
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11000-17-2/Vasopressins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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