| Effect of cooling after human cardiac arrest on myocardial infarct size. | |
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MedLine Citation:
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PMID: 18951682 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: The Hypothermia after Cardiac Arrest (HACA) trial assessed whether mild therapeutic hypothermia improved the rate of good neurological recovery in patients after ventricular fibrillation cardiac arrest of presumed cardiac origin. We evaluated the impact of hypothermia on myocardial injury. METHODS: Re-analysis of a HACA trial subset for our department (cooling, n=55; controls, n=56). Plasma levels of CK, CKMB and ST-scores were used as a measure of infarct size. RESULTS: Area under the curve (AUC) for CK was 28,786U/l x 24 h (IQR 5646-44,998) in the cooling group and 20,373U/l x 24 h (IQR 8211-30,801) for controls (p=0.40), for CKMB AUC was 1691U/l x 24 h (IQR 724-3330) and 1187U/l x 24 h (IQR 490-2469), respectively (p=0.18). The ST score was -40% (IQR [-55]-[+16]) in the cooling group (n=23) and -22% (IQR [-84]-[+33]) for controls (n=24) (p=0.76). When the cooling group was stratified into early (< or =8h) and longer (>8h) time to target temperature, the early group displayed a significantly lower CK 7340U/l x 24 h (IQR 3921-33,753) vs. 38,986U/l x 24 h (IQR 23,945-57,514, p=0.007) and a lower CKMB. CONCLUSION: Cooling after successful resuscitation for ventricular fibrillation cardiac arrest did not influence infarct size. Cautious interpretation of the subgroup analysis may indicate a favourable trend for early cooling. |
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Authors:
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Maria Koreny; Fritz Sterz; Thomas Uray; Wolfgang Schreiber; Michael Holzer; Anton Laggner; Harald Herkner |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2008-10-31 |
Journal Detail:
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Title: Resuscitation Volume: 80 ISSN: 0300-9572 ISO Abbreviation: Resuscitation Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-23 Completed Date: 2009-03-10 Revised Date: 2009-08-25 |
Medline Journal Info:
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Nlm Unique ID: 0332173 Medline TA: Resuscitation Country: Ireland |
Other Details:
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Languages: eng Pagination: 56-60 Citation Subset: IM |
Affiliation:
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Department of Emergency Medicine, Medical University Vienna, Vienna General Hospital, Waehringer Guertel 18-20/6D, A-1090 Vienna, Austria. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Creatine Kinase, MB Form / blood Electrocardiography Female Heart Arrest / blood, diagnosis, therapy* Humans Hypothermia, Induced* Male Middle Aged Myocardial Infarction / blood, diagnosis, therapy* Resuscitation / methods Severity of Illness Index Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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EC 2.7.3.2/Creatine Kinase, MB Form |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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