Document Detail

Effect of cooking on veterinary drug residues in food. Part 9. Nitroimidazoles.
MedLine Citation:
PMID:  10605889     Owner:  NLM     Status:  MEDLINE    
Most food containing drug residues is consumed after cooking or processing, yet surveillance for these residues is almost always conducted on raw tissue. This investigation was to establish the effect of cooking on residues of the nitroimidazole drugs dimetridazole and ronidazole in chicken muscle and egg, to enable dietary intake calculations based on surveillance results. In model aqueous and lipid solutions, dimetridazole and its 2-hydroxy metabolite, which is usually found when residues are present, were relatively stable for times and temperatures normally encountered during standard cooking methods. Ronidazole in hot aqueous solutions, except at acidic pH, was converted into the 2-hydroxy metabolite. Chicken meat and eggs from birds treated with dimetridazole or ronidazole were used to investigate the effects of cooking on food containing these residues. It was apparent that these residues were not destroyed by cooking chicken meat although some of the residue leached from the sample with juices which exuded as it cooked. Residue concentration in egg reduced during cooking by between 14% and 32% of the original concentration.
M D Rose; J Bygrave; M Sharman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Analyst     Volume:  124     ISSN:  0003-2654     ISO Abbreviation:  Analyst     Publication Date:  1999 Mar 
Date Detail:
Created Date:  2000-01-11     Completed Date:  2000-01-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372652     Medline TA:  Analyst     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  289-94     Citation Subset:  IM    
CSL Food Science Laboratory, Norwich Research Park, Colney, UK.
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MeSH Terms
Antiprotozoal Agents / chemistry*
Drug Residues*
Food Contamination*
Nitroimidazoles / chemistry*
Reg. No./Substance:
0/Antiprotozoal Agents; 0/Nitroimidazoles

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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