Document Detail

Effect of continuous positive airway pressure on breathing pattern of infants with respiratory-distress syndrome.
MedLine Citation:
PMID:  46446     Owner:  NLM     Status:  MEDLINE    
The effect of continuous positive airway pressure (C.P.A.P.) on the breathing pattern of ten newborn infants with respiratory-distress syndrome (R.D.S.) has been studied using an impedance pneumograph; arterial oxygenation improved and respiration, previously disorganized, became regular in both rate and depth. Grunting usually ceased within 15 minutes of the start of C.P.A.P., and there was also on average a 30 percent increase in the respiratory-rate. The rapidity with which the breathing pattern changed suggests a reflex mechanism. Sudden reductions in airway pressure were frequently followed by apnoea, regular breathing restarting with the reintroduction of C.P.A.P. These observations suggest that C.P.P.A. provides a respiratory drive in babies with R.D.S., possibly mediated through the Hering-Breuer inflation reflex.
B D Speidel; P M Dunn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lancet     Volume:  1     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1975 Feb 
Date Detail:
Created Date:  1975-05-09     Completed Date:  1975-05-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  302-4     Citation Subset:  AIM; IM    
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MeSH Terms
Apnea / diagnosis
Birth Weight
Blood Pressure
Bradycardia / diagnosis
Carbon Dioxide / blood
Heart / physiopathology
Heart Rate
Infant, Newborn
Lung / physiopathology
Oxygen / blood
Plethysmography, Impedance
Positive-Pressure Respiration*
Pulmonary Alveoli / blood supply
Respiratory Distress Syndrome, Newborn / blood,  physiopathology,  therapy*
Respiratory Function Tests
Time Factors
Ventilation-Perfusion Ratio
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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