| Effect of continuous administration of conjugated estrogen plus medroxyprogesterone acetate (Premelle) in postmenopausal women in Taiwan. | |
| | |
MedLine Citation:
|
PMID: 15510930 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: To compare the metabolic effects on lipids and acceptability and safety of, and compliance with, a continuous administration of conjugated estrogen plus medroxyprogesterone acetate (Premelle) versus a placebo in non-hysterectomized postmenopausal women. METHODS: Sixty-six generally healthy, female, early post-menopausal women, from 45-60 years of age, were randomized for an administration of conjugated estrogen plus medroxyprogesterone acetate (Premelle, Premarin 0.625 mg plus medroxyprogesterone acetate 2.5 mg/tablet orally) or a placebo for 6 months. The changes in each patient's lipid profiles from baseline, the frequency of hot flushes, bleeding occurrences, and climacteric symptoms, were evaluated. Safety was monitored by means of physical examination, Papanicolau smear, transvaginal ultrasonography, and laboratory check-up. Adverse events were also recorded. RESULTS: The difference before and after treatment in serum LDL-C and total cholesterol (TC) was statistically significant in the Premelle group (LDL-C, p = 0.006, TC, p = 0.040). No statistically significant difference in the change from baseline was observed in the levels of LDL-C and TC in the placebo treatment group. There was a statistically significant change from baseline in menopausal symptoms, which were evaluated by the Greene Climacteric Scales in the Premelle group. There was no clinically significant finding in the physical examination, vital signs, laboratory data, or endometrial thickness in either treatment group. The difference in the number of patients who reported an adverse event was not statistically significant between the 2 treatment groups. CONCLUSIONS: This study demonstrated that Premelle was effective in decreasing LDL-C and total cholesterol levels, and also showed an improvement in some menopausal symptoms, such as vasomotor and sexual dysfunction symptoms. No significant bleeding was observed with Premelle, which was well tolerated in this study. The results of this study could support the use of Premelle tablets as a convenient alternative hormone therapy. |
| | |
Authors:
|
Tzay-Shing Yang; Huai-Ling Wang; Yi-Jen Chen; Sheng-Ping Chang; Chiou-Chung Yuan |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Journal of the Chinese Medical Association : JCMA Volume: 67 ISSN: 1726-4901 ISO Abbreviation: J Chin Med Assoc Publication Date: 2004 Jul |
Date Detail:
|
Created Date: 2004-10-29 Completed Date: 2005-01-05 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 101174817 Medline TA: J Chin Med Assoc Country: China (Republic: 1949- ) |
Other Details:
|
Languages: eng Pagination: 336-43 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan, ROC. chenyj@vghtpe.gov.tw |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cholesterol, HDL
/
blood,
drug effects Cholesterol, LDL / blood, drug effects Contraceptives, Oral, Synthetic / administration & dosage, adverse effects, pharmacology Double-Blind Method Estrogens / administration & dosage, adverse effects, pharmacology Estrogens, Conjugated (USP) / administration & dosage, adverse effects, pharmacology* Female Follow-Up Studies Humans Medroxyprogesterone / administration & dosage, adverse effects, pharmacology* Menopause / drug effects Middle Aged Outpatients Pharyngitis / chemically induced Postmenopause / blood, drug effects* Sexual Behavior / drug effects Taiwan Time Factors Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
|
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Contraceptives, Oral, Synthetic; 0/Estrogens; 0/Estrogens, Conjugated (USP); 0/Triglycerides; 520-85-4/Medroxyprogesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Significance of pulmonary venous obstruction in total anomalous pulmonary venous return.
Next Document: The experience with Ritleng intubation system in patients with congenital nasolacrimal duct obstruct...