Document Detail

Effect of conscious sedation with midazolam on oxygen saturation.
MedLine Citation:
PMID:  3166044     Owner:  NLM     Status:  MEDLINE    
A randomized cross-over study was done to determine if significant oxygen desaturation occurs during third molar surgery under conscious sedation with midazolam to warrant supplementary oxygen. Thirty-two healthy patients of either sex, between the ages of 18 and 40 years, had bilateral symmetrically impacted lower third molar surgery under local anesthesia in two visits. Randomly at one visit the local anesthesia was supplemented with midazolam sedation. Continuous monitoring of oxygen saturation, blood pressure, and pulse were carried out. At the rate of injection with the dose of midazolam used, no significant desaturation attributable to midazolam sedation was observed. However, short periods of significant desaturation occurred with both procedures. These episodes, though of no consequence to healthy people, may produce problems in compromised patients, and indicate the importance of monitoring of oxygen saturation in all patients during minor oral surgery procedures.
M R Rodrigo; J B Rosenquist
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons     Volume:  46     ISSN:  0278-2391     ISO Abbreviation:  J. Oral Maxillofac. Surg.     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-10-13     Completed Date:  1988-10-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8206428     Medline TA:  J Oral Maxillofac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  746-50     Citation Subset:  AIM; D; IM    
Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Hong Kong.
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MeSH Terms
Anesthesia, Dental
Anesthesia, Intravenous
Anoxia / chemically induced
Midazolam / pharmacology*
Oxygen / blood*
Preanesthetic Medication*
Random Allocation
Tooth Extraction*
Reg. No./Substance:
59467-70-8/Midazolam; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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