| Effect of a conjugated acridine moiety on the binding and reactivity of Cu(II)[9-acridinylmethyl-1,4,7-triazacyclononane] with DNA. | |
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MedLine Citation:
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PMID: 15522405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The DNA binding orientation and dynamic behavior of Cu(II) complexes of 1,4,7-triazacyclononane ([9]aneN(3)), 1, and an acridine conjugate, 2, were investigated by DNA fiber EPR (EPR=electron paramagnetic resonance) spectroscopy. Crystal and molecular structure of 2 were determined by X-ray diffraction. It has been shown that 1 binds to DNA in two different modes at room temperature; one species is rapidly rotating and the other is immobilized randomly on the DNA. The introduction of acridine to [9]aneN(3) fixed the [Cu([9]aneN(3))](2+) moiety of 2 in two different environments on the DNA: the g(mid R:mid R:) axis of one species (g( parallel)=2.26) is aligned perpendicularly to the DNA fiber axis whereas that of the other (g( parallel)=2.24) aligns<90 degrees with the DNA fiber axis. The different DNA binding structures of 1 and 2 are reflected also in their different efficiencies of DNA cleavage; 2 was found to be more effective both in oxidative and hydrolytic cleavage reactions. |
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Authors:
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Tomoya Hirohama; Hidekazu Arii; Makoto Chikira |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of inorganic biochemistry Volume: 98 ISSN: 0162-0134 ISO Abbreviation: J. Inorg. Biochem. Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-11-03 Completed Date: 2005-10-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7905788 Medline TA: J Inorg Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 1778-86 Citation Subset: IM |
Affiliation:
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Department of Applied Chemistry, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, 112-8551 Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acridines
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chemical synthesis,
chemistry*,
pharmacology Animals Bacteriophage phi X 174 Cattle DNA / chemistry*, drug effects DNA, Viral / chemistry, drug effects Electron Spin Resonance Spectroscopy Magnetic Resonance Spectroscopy Male Models, Molecular Organometallic Compounds / chemical synthesis, chemistry*, pharmacology Salmon Testis Thymus Gland |
| Chemical | |
Reg. No./Substance:
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0/Acridines; 0/Cu(II)(9-acridinylmethyl-1,4,7-triazacyclononane); 0/DNA, Viral; 0/Organometallic Compounds; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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