Document Detail

Effect of conjugated FA on feed intake, body composition, and liver FA in mice.
MedLine Citation:
PMID:  14584596     Owner:  NLM     Status:  MEDLINE    
CLA is a generic term describing different isomers of linoleic acid with two conjugated double bonds. Various metabolic effects have been demonstrated following administration of CLA, including a change in body composition in animals. However, the effects of pure CLA isomers are not fully understood. In addition, conjugated octadecatrienoic acids such as calendic acid have not been extensively investigated. In this study, male and female ICR mice were fed pure CLA isomers (cis9,trans11 or trans10,cis12) or calendic acid (trans8,trans10,cis12) as their ethyl esters for 6 wk. Body protein content was significantly increased after feeding CLA isomers, either as pure isomers or as a mixture. Calendic acid significantly decreased body fat content in males. CLA (pure isomers or a mixture) significantly decreased body fat in both males and females, with the trans10,cis12 isomer being the most effective. The effect of the cis9,trans11 isomer was more pronounced in females than in males. It was concluded that the trans10,cis12 CLA isomer was mainly responsible for the decrease in fat content in mice, without a significant modification of feed efficiency, and that it was more effective than calendic acid.
J M Chardigny; O Hasselwander; M Genty; K Kraemer; A Ptock; J L Sébédio
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lipids     Volume:  38     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-10-30     Completed Date:  2004-06-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  895-902     Citation Subset:  IM    
Institut National de la Recherche Agronomique, Unité de Nutrition Lipidique, 21065 Dijon, France.
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MeSH Terms
Body Composition / drug effects*
Body Weight / drug effects
Fatty Acids / metabolism*
Feeding Behavior / drug effects*
Linoleic Acids, Conjugated / administration & dosage,  chemistry,  pharmacology*
Liver / drug effects*,  metabolism
Mice, Inbred ICR
Molecular Structure
Organ Size / drug effects
Phospholipids / metabolism
Sex Characteristics
Reg. No./Substance:
0/Fatty Acids; 0/Linoleic Acids, Conjugated; 0/Phospholipids

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