| Effect of congenital heart disease on neurodevelopmental outcomes within multiple-gestation births. | |
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MedLine Citation:
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PMID: 16307991 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We sought to assess the effect of congenital heart disease requiring surgical intervention with cardiopulmonary bypass at 6 months of age or less on developmental outcomes and growth at 1 year of age while controlling for socioeconomic status, prematurity, home environment, and parental intelligence. METHODS: We performed within-family comparison of 11 multiple-gestation births in which one child had congenital heart disease. At 1 year of age, the Bayley Scales of Infant Development II were administered, and growth parameters were assessed. Paired comparisons were made by using fixed effects regression conditioned on family. RESULTS: The multiple-gestation subjects were mildly premature on average (mean gestational age, 35.4 +/- 3.0 weeks). At 1 year of age, children with congenital heart disease scored lower on the Mental Development Index (85.0 +/- 19.3 vs 93.9 +/- 16.0, P = .037) and the Psychomotor Development Index (76.6 +/- 16.9 vs 91.3 +/- 14.9, P = .015) on the Bayley Scales of Infant Development II than did their siblings without congenital heart disease. There were no differences between siblings in weight, height, or head circumference. CONCLUSIONS: The presence of congenital heart disease requiring surgical intervention with cardiopulmonary bypass at 6 months of age or less is associated with a deficit in developmental achievement at 1 year of age, as measured by using the Bayley Scales of Infant Development II. |
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Authors:
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Amy H Schultz; Gail P Jarvik; Gil Wernovsky; Judy Bernbaum; Robert R Clancy; Jo Ann D'Agostino; Marsha Gerdes; Donna McDonald-McGinn; Susan C Nicolson; Thomas L Spray; Elaine Zackai; J William Gaynor |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of thoracic and cardiovascular surgery Volume: 130 ISSN: 1097-685X ISO Abbreviation: J. Thorac. Cardiovasc. Surg. Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-11-25 Completed Date: 2006-03-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376343 Medline TA: J Thorac Cardiovasc Surg Country: United States |
Other Details:
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Languages: eng Pagination: 1511-6 Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiology, The Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine, Philadelphia, Pa, USA. ahschultz@uwalumni.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Heart Diseases / complications*, congenital* Humans Infant Male Psychomotor Disorders / epidemiology*, etiology* Triplets* Twins* |
| Grant Support | |
ID/Acronym/Agency:
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T32-HL07915/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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