| Effect of concurrent exercise and physostigmine on lactate and pyruvate in plasma, muscle, and brain tissue of rats. | |
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MedLine Citation:
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PMID: 8029245 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this investigation was to determine the effect of physostigmine (Phy) and/or concurrent exercise on lactate, pyruvate, and L/P ratio in plasma, skeletal muscle, and brain tissue in male Sprague-Dawley rats. The Phy-dosed (Phy-D) and Phy-dosed + concurrent acute exercise (Phy-D + CAE) groups elicited significantly higher L/P ratios in plasma compared to the acutely exercised (AE) group at 30 min postexercise. Physostigmine dosing, with or without exercise, resulted in significantly lower muscle pyruvate levels, from 30 to 50 min postdrug administration, in Phy-D and Phy-D + CAE groups compared to the AE group. In the brain, lactate values were significantly elevated in the acutely exercised groups at 5 min postexercise with or without Phy dosing. However, at 15 to 30 min postexercise, lactate values were significantly elevated in the Phy-D + CAE compared to the AE group. These data suggest that when Phy is administered prior to a 20-min moderately intensive exercise bout, there is an accumulation of lactate for a prolonged period of time in recovery. |
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Authors:
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P J Buckenmeyer; S R Babu; R G Knowlton; S M Somani |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 47 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1994 Apr |
Date Detail:
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Created Date: 1994-08-08 Completed Date: 1994-08-08 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 779-88 Citation Subset: IM; S |
Affiliation:
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Department of Health and Physical Education, Syracuse University, NY 13244-5040. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / drug effects, metabolism Kinetics Lactates / blood, metabolism* Lactic Acid Male Muscles / drug effects, metabolism Physical Exertion / physiology* Physostigmine / pharmacology* Pyruvates / blood, metabolism* Pyruvic Acid Rats Rats, Sprague-Dawley Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 0/Pyruvates; 127-17-3/Pyruvic Acid; 50-21-5/Lactic Acid; 57-47-6/Physostigmine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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