Document Detail

Effect of concomitant use of latanoprost and brinzolamide on 24-hour variation of IOP in normal-tension glaucoma.
MedLine Citation:
PMID:  17570997     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To study the effect of the concomitant use of latanoprost and brinzolamide on the 24-hour variation in the intraocular pressure (IOP) in patients with normal-tension glaucoma (NTG). METHODS: We studied a total of 44 eyes from 22 NTG patients. Mean 24-hour IOP variation was determined after a washout period of > or =4 weeks. Latanoprost monotherapy was continued in both eyes for 8 weeks. Thereafter, patients were randomized to continue latanoprost monotherapy in 1 eye whereas brinzolamide was added as an adjunct to latanoprost therapy in the other eye. Eight weeks after the initiation of brinzolamide treatment, the 24-hour IOP variation was remeasured. IOP was measured in the sitting position 8 times daily using a Goldmann applanation tonometer before and after treatment. RESULTS: The eyes treated with latanoprost monotherapy and those treated with latanoprost and brinzolamide showed a significant decrease in IOP at all time points. Percent reductions in the diurnal mean IOP (mean IOP at 10 AM, 1 PM, and 4 PM) and in nocturnal mean IOP (mean IOP at 10 PM, 1 AM, and 3 AM) were significantly greater in the eyes treated with the combination of latanoprost and brinzolamide than those with latanoprost alone (diurnal mean IOP: latanoprost and brinzolamide=19.8%, latanoprost=14.1%, P<0.001; nocturnal mean IOP: latanoprost and brinzolamide=13.4%, latanoprost=10.0%, P<0.05). CONCLUSIONS: For the treatment of NTG, the combination of latanoprost and brinzolamide demonstrated additive effects in lowering IOP, not only during the day, but also at night.
Kenji Nakamoto; Noriko Yasuda
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of glaucoma     Volume:  16     ISSN:  1057-0829     ISO Abbreviation:  J. Glaucoma     Publication Date:    2007 Jun-Jul
Date Detail:
Created Date:  2007-06-15     Completed Date:  2007-08-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9300903     Medline TA:  J Glaucoma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  352-7     Citation Subset:  IM    
Tokyo Metropolitan Police Hospital, Tokyo, Japan.
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MeSH Terms
Antihypertensive Agents / administration & dosage,  therapeutic use*
Blood Pressure
Cell Count
Circadian Rhythm / drug effects*,  physiology
Drug Therapy, Combination
Endothelium, Corneal / drug effects,  pathology
Glaucoma, Open-Angle / drug therapy*,  physiopathology
Heart Rate
Intraocular Pressure / drug effects*,  physiology
Middle Aged
Prostaglandins F, Synthetic / administration & dosage,  therapeutic use*
Sulfonamides / administration & dosage,  therapeutic use*
Thiazines / administration & dosage,  therapeutic use*
Tonometry, Ocular
Reg. No./Substance:
0/Antihypertensive Agents; 0/Prostaglandins F, Synthetic; 0/Sulfonamides; 0/Thiazines; 130209-82-4/latanoprost; 138890-62-7/brinzolamide

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