| Effect of concomitant use of latanoprost and brinzolamide on 24-hour variation of IOP in normal-tension glaucoma. | |
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MedLine Citation:
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PMID: 17570997 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To study the effect of the concomitant use of latanoprost and brinzolamide on the 24-hour variation in the intraocular pressure (IOP) in patients with normal-tension glaucoma (NTG). METHODS: We studied a total of 44 eyes from 22 NTG patients. Mean 24-hour IOP variation was determined after a washout period of > or =4 weeks. Latanoprost monotherapy was continued in both eyes for 8 weeks. Thereafter, patients were randomized to continue latanoprost monotherapy in 1 eye whereas brinzolamide was added as an adjunct to latanoprost therapy in the other eye. Eight weeks after the initiation of brinzolamide treatment, the 24-hour IOP variation was remeasured. IOP was measured in the sitting position 8 times daily using a Goldmann applanation tonometer before and after treatment. RESULTS: The eyes treated with latanoprost monotherapy and those treated with latanoprost and brinzolamide showed a significant decrease in IOP at all time points. Percent reductions in the diurnal mean IOP (mean IOP at 10 AM, 1 PM, and 4 PM) and in nocturnal mean IOP (mean IOP at 10 PM, 1 AM, and 3 AM) were significantly greater in the eyes treated with the combination of latanoprost and brinzolamide than those with latanoprost alone (diurnal mean IOP: latanoprost and brinzolamide=19.8%, latanoprost=14.1%, P<0.001; nocturnal mean IOP: latanoprost and brinzolamide=13.4%, latanoprost=10.0%, P<0.05). CONCLUSIONS: For the treatment of NTG, the combination of latanoprost and brinzolamide demonstrated additive effects in lowering IOP, not only during the day, but also at night. |
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Authors:
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Kenji Nakamoto; Noriko Yasuda |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of glaucoma Volume: 16 ISSN: 1057-0829 ISO Abbreviation: J. Glaucoma Publication Date: 2007 Jun-Jul |
Date Detail:
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Created Date: 2007-06-15 Completed Date: 2007-08-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9300903 Medline TA: J Glaucoma Country: United States |
Other Details:
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Languages: eng Pagination: 352-7 Citation Subset: IM |
Affiliation:
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Tokyo Metropolitan Police Hospital, Tokyo, Japan. user902850@aol.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Antihypertensive Agents
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administration & dosage,
therapeutic use* Blood Pressure Cell Count Circadian Rhythm / drug effects*, physiology Drug Therapy, Combination Endothelium, Corneal / drug effects, pathology Female Glaucoma, Open-Angle / drug therapy*, physiopathology Heart Rate Humans Intraocular Pressure / drug effects*, physiology Male Middle Aged Prostaglandins F, Synthetic / administration & dosage, therapeutic use* Sulfonamides / administration & dosage, therapeutic use* Thiazines / administration & dosage, therapeutic use* Tonometry, Ocular |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Prostaglandins F, Synthetic; 0/Sulfonamides; 0/Thiazines; 130209-82-4/latanoprost; 138890-62-7/brinzolamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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