Document Detail

Effect of the conceptus on uterine prostaglandin-F2alpha and prostaglandin-E2 release and synthesis during the periimplantation period in the pig.
MedLine Citation:
PMID:  19486608     Owner:  NLM     Status:  MEDLINE    
The present study was conducted to evaluate the effect of the conceptus on uterine prostaglandin-F2alpha (PGF2alpha) and prostaglandin-E2 (PGE2) release and the expression of prostaglandin synthase enzymes during the periimplantation period in the pig. A surgically generated model with conceptuses developing in only one of the uterine horns was created. The highest concentration of PGF2alpha and PGE2 was found in the gravid uterine horn, compared with the non-gravid horn and the intact horn of cyclic gilts. Endometrial concentration of both PGs in pregnant gilts was elevated regardless of the conceptus in the uterine horn, whereas only myometrial PGE2 concentration increased during pregnancy. Expression of prostaglandin-E2 synthase (mPGES-1) mRNA in the endometrium was upregulated during the oestrous cycle, while protein expression presented a similar pattern to that of PGE2 concentration in the uterine flushings. Prostaglandin-F2alpha synthase (PGFS) mRNA and protein expression in the endometrium did not differ between pregnancy and oestrous cycle but PGFS mRNA in the myometrium increased during pregnancy both in the gravid and the non-gravid uterine horns. We suggest a local effect of the conceptus on PG release pathways but also a more systemic effect within the whole uterus with regard to PG synthesis and accumulation in uterine tissues.
Marta Wasielak; Katarzyna Kamińska; Marek Bogacki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Reproduction, fertility, and development     Volume:  21     ISSN:  1031-3613     ISO Abbreviation:  Reprod. Fertil. Dev.     Publication Date:  2009  
Date Detail:
Created Date:  2009-06-02     Completed Date:  2009-08-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8907465     Medline TA:  Reprod Fertil Dev     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  709-17     Citation Subset:  IM    
Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Tuwima 10, 10-747 Olsztyn, Poland.
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MeSH Terms
Dinoprost / metabolism*
Dinoprostone / metabolism*
Embryo Implantation / physiology*
Endometrium / metabolism
Estradiol / metabolism
Hydroxyprostaglandin Dehydrogenases / metabolism
Intramolecular Oxidoreductases / metabolism
Models, Animal
Models, Biological
Myometrium / metabolism
Pregnancy / metabolism*
RNA, Messenger / metabolism
Swine / metabolism*
Uterus / metabolism*
Reg. No./Substance:
0/RNA, Messenger; 363-24-6/Dinoprostone; 50-28-2/Estradiol; 551-11-1/Dinoprost; EC 1.1.1.-/Hydroxyprostaglandin Dehydrogenases; EC synthase; EC 5.3.-/Intramolecular Oxidoreductases; EC synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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