Document Detail

Effect of combined treatment with aflatoxin B1 and T-2 toxin and metabolites on some production traits and lipid peroxide status parameters of broiler chickens.
MedLine Citation:
PMID:  19457776     Owner:  NLM     Status:  MEDLINE    
Three groups of cockerels were fed with a control diet, with a diet contaminated with T-2 and HT-2 toxin (0.31 and 0.26 mg/kg) or with that containing a combination of T-2 and HT-2 toxin (0.32 and 0.25 mg/kg) and aflatoxin B1 (AFB1, 0.38 mg/kg) for 21 days. Body weight gain and feed conversion ratio did not differ significantly among the groups. Malondialdehyde concentration of the liver was lower in the group fed the diet contaminated with the combination of T-2 + HT-2 toxin and aflatoxin B1 as compared to the control group or the group fed T-2 + HT-2 toxins. Reduced glutathione (GSH) content of the liver was lower in the T-2 + HT-2 group than in the group fed a combination of T-2, HT-2 and aflatoxin. Reduced glutathione content of the heart was higher in the T-2 + HT-2 group than in the control group. Mycotoxin contamination had no effect on glutathione peroxidase (GSH-Px) activity in comparison to the control, but significantly lower GSH-Px activity was found in the heart of chickens in the T-2 + HT-2 + AFB1 group than in the T-2 + HT-2 group. In this study, T-2 + HT-2 toxin and aflatoxin B1 contamination of the diets did not affect the production traits adversely and did not exert additive effects on lipid peroxidation and on the glutathione redox system.
László Pál; Károly Dublecz; Mária Weber; Krisztián Balogh; Márta Erdélyi; Gábor Szigeti; Miklós Mézes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta veterinaria Hungarica     Volume:  57     ISSN:  0236-6290     ISO Abbreviation:  Acta Vet. Hung.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-05-22     Completed Date:  2009-06-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406376     Medline TA:  Acta Vet Hung     Country:  Hungary    
Other Details:
Languages:  eng     Pagination:  75-84     Citation Subset:  IM    
Department of Animal Science and Animal Husbandry, Georgikon Faculty of Agriculture, Pannon University, Keszthely, Hungary.
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MeSH Terms
Aflatoxin B1 / toxicity*
Body Weight / drug effects
Chickens / growth & development*,  metabolism
Eating / drug effects
Lipid Peroxidation / drug effects
Lipid Peroxides / metabolism*
Random Allocation
T-2 Toxin / analogs & derivatives*,  toxicity*
Reg. No./Substance:
0/Lipid Peroxides; 1162-65-8/Aflatoxin B1; 21259-20-1/T-2 Toxin; 26934-87-2/HT-2 toxin

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