Document Detail


EFFECT OF COMBINED CATARACT SURGERY AND RANIBIZUMAB INJECTION IN POSTOPERATIVE MACULAR EDEMA IN NONPROLIFERATIVE DIABETIC RETINOPATHY.
MedLine Citation:
PMID:  23807186     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
PURPOSE:: To evaluate whether intravitreal ranibizumab injection at cataract surgery prevents postoperative diabetic macular edema (PME) in patients with stable diabetic retinopathy without significant macular edema.
METHODS:: Eighty patients with cataract, stable diabetic retinopathy, and no significant macular edema were randomized to a sham group (cataract surgery only) or a group undergoing cataract surgery plus intraoperative ranibizumab injection. Best-corrected visual acuities, central subfield thickness, and total macular volume were assessed at baseline and 1 week, 1, 3, and 6 months postoperatively by spectral domain optical coherence tomography. Clinically meaningful PME (central subfield thickness increase >60 μm relative to baseline) was computed.
RESULTS:: The groups did not differ in baseline best-corrected visual acuity, central subfield thickness, and total macular volume. Compared with the ranibizumab injection group, the sham group had significantly larger central subfield thickness increases relative to baseline at 1 week and 1 month; larger total macular volume increases at all time points (P = 0.012, P = 0.005, P < 0.001, P < 0.001, P = 0.005, P = 0.017, respectively); higher PME frequency at 1 month (P = 0.019); and poorer best-corrected visual acuity improvement from baseline to 6 months after surgery (P = 0.046).
CONCLUSION:: In patients with stable diabetic retinopathy without significant macular edema, intravitreal ranibizumab injection at cataract surgery may prevent the postoperative worsening of macular edema and may improve the final visual outcome without affecting safety.
Authors:
Ju Byung Chae; Soo Geun Joe; Sung Jae Yang; Joo Yong Lee; Kyung Rim Sung; Jae Yong Kim; June-Gone Kim; Young Hee Yoon
Related Documents :
12182256 - A randomized, double-blind comparison of a clindamycin phosphate/benzoyl peroxide gel f...
10568486 - Clinical trial of the efficacy and safety of oral etretinate with calcipotriol cream co...
3157706 - An accurate photographic method for grading acne: initial use in a double-blind clinica...
14725326 - Ajoene and 5-fluorouracil in the topical treatment of cladophialophora carrionii chromo...
2482536 - A randomized controlled open study of interferon alpha-2b treatment of chronic non-a, n...
25437716 - Transcervical intralesional vasopressin injection compared with placebo in hysteroscopi...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-6-25
Journal Detail:
Title:  Retina (Philadelphia, Pa.)     Volume:  -     ISSN:  1539-2864     ISO Abbreviation:  Retina (Philadelphia, Pa.)     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-6-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309919     Medline TA:  Retina     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
*Department of Ophthalmology, College of Medicine, Chungbuk National University, Cheongju, Korea; †Department of Ophthalmology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea; and ‡Department of Ophthalmology, Gangneung Asan Hospital, College of Medicine, University of Ulsan, Gangneung, Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  CORNEAL ENDOTHELIAL CELL DENSITY AFTER VITRECTOMY WITH SILICONE OIL FOR COMPLEX RETINAL DETACHMENTS.
Next Document:  CHANGING PROFILE OF ORGANISMS CAUSING SCLERAL BUCKLE INFECTIONS: A Clinico-microbiological Case Seri...