| Effect of the combination of naltrexone and acamprosate on alcohol intake in mice. | |
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MedLine Citation:
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PMID: 14678454 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Both naltrexone and acamprosate have been utilized clinically in recovering alcoholics with varying success. In the experiment reported here the combination of naltrexone and acamprosate was examined in a limited access alcohol model using C57BL/6 mice to determine if there was evidence of additive or synergistic effects. The results of this experiment demonstrate that naltrexone, at the higher dose but not the lower dose, significantly reduced alcohol consumption. When combined with naltrexone, acamprosate reduced alcohol consumption across both doses of naltrexone. This effect was sensitive to both dose and number of days of exposure to the naltrexone/acamprosate combination. |
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Authors:
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Sung-Gon Kim; Byeung-Deuk Han; Je-Min Park; Myung-Jung Kim; Michael F Stromberg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Psychiatry and clinical neurosciences Volume: 58 ISSN: 1323-1316 ISO Abbreviation: Psychiatry Clin. Neurosci. Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2003-12-17 Completed Date: 2004-05-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9513551 Medline TA: Psychiatry Clin Neurosci Country: Australia |
Other Details:
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Languages: eng Pagination: 30-6 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, School of Medicine, Pusan National University, Pusan, Korea. sungkim@pusan.ac.kr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Deterrents
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pharmacokinetics,
pharmacology* Alcohol Drinking* Alcoholism / drug therapy Animals Dose-Response Relationship, Drug Drug Therapy, Combination Male Mice Mice, Inbred C57BL Naltrexone / pharmacokinetics, pharmacology* Narcotic Antagonists / pharmacokinetics, pharmacology* Taurine / analogs & derivatives*, pharmacokinetics, pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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KO1-AA00228/AA/NIAAA NIH HHS; R01AA-07517/AA/NIAAA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Alcohol Deterrents; 0/Narcotic Antagonists; 107-35-7/Taurine; 16590-41-3/Naltrexone; 77337-76-9/acamprosate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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