Document Detail


Effect of colectomy on cholecystokinin and gastrin release.
MedLine Citation:
PMID:  7149821     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies were conducted to determine the effect of resection of the colon on the release of cholecystokinin (CCK) and gastrin. A standard food stimulation test was performed in five dogs. Peripheral blood samples were collected for future measurement of CCK and gastrin by specific radioimmunoassay. Each dog underwent subtotal colectomy with side-to-end ileoproctostomy. The food stimulation test was repeated at approximately weekly intervals for eight weeks after colectomy. Basal plasma CCK levels of 139 +/- 21 pg/ml before colectomy did not change after colectomy. Total amount CCK released after food was increased significantly at both four (5.94 +/- 0.78 ng min/ml) and eight (13.00 +/- 2.72 ng min/ml) weeks after colectomy in comparison with that observed prior to colectomy (2.94 +/- 0.54 ng min/ml). Basal serum gastrin levels of 28 +/- 9 pg/ml did not change significantly after colectomy. Total amount of gastrin released after food was increased significantly at both two (8651 +/- 2294 pg min/ml) and three (6940 +/- 1426 pg min/ml) weeks after operation, but at none of the later weeks. The precolectomy output, used for comparison, was 5608 +/- 1346 pg min/ml. It was concluded that resection of the colon leads to an increase in release of CCK and gastrin after food stimulation. This finding provides further evidence that the colon contains a factor that inhibits the release of CCK and gastrin, and that the colon functions as an endocrine organ.
Authors:
K Inoue; I Wiener; G M Fried; P Lilja; L C Watson; J C Thompson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of surgery     Volume:  196     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  1982 Dec 
Date Detail:
Created Date:  1983-01-07     Completed Date:  1983-01-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  691-4     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cholecystokinin / blood,  secretion*
Colectomy*
Dogs
Food
Gastrins / blood,  secretion*
Grant Support
ID/Acronym/Agency:
AM 15241/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Gastrins; 9011-97-6/Cholecystokinin
Comments/Corrections

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