Document Detail

Effect of cold-temperature exposure and acclimation on amino acid pool changes and enzyme activities of rat brown adipose tissue.
MedLine Citation:
PMID:  2887209     Owner:  NLM     Status:  MEDLINE    
The amino acid pool composition and its concentration ratios with respect to blood and plasma, as well as the activities of alanine, aspartate and branched chain amino acid transaminases, glutamine synthetase, adenylate deaminase and glutamate dehydrogenase have been studied in the interscapular brown adipose tissue of control, 12-h cold-exposed and 15-day cold-acclimated rats. Cold temperature affected the amino acid metabolism and pool composition more intensely after 15 days than after 12-h cold-exposure, even though the patterns of change were very similar in both groups. Cold temperatures induced a decrease in glutamine and an increase in glutamate concentration in the tissue. This probably increased the metabolism of branched chain amino acids and caused a decrease in adenylate deaminase activity. It also seemed to increase alanine utilization. We concluded that amino acid metabolism in brown adipose tissue is enhanced by cold temperature acclimation.
F J López-Soriano; M Alemany
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  925     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1987-10-19     Completed Date:  1987-10-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  265-71     Citation Subset:  IM    
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MeSH Terms
AMP Deaminase / metabolism
Adipose Tissue, Brown / enzymology,  metabolism*
Amino Acids / metabolism*
Cold Temperature*
Glutamate Dehydrogenase / metabolism
Glutamate-Ammonia Ligase / metabolism
Rats, Inbred Strains
Transaminases / metabolism
Reg. No./Substance:
0/Amino Acids; EC Dehydrogenase; EC 2.6.1.-/Transaminases; EC Deaminase; EC Ligase

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