Document Detail

Effect of coffee on motor and sensory function of proximal stomach.
MedLine Citation:
PMID:  11341663     Owner:  NLM     Status:  MEDLINE    
Some people attribute dyspeptic symptoms to drinking coffee, suggesting that coffee affects one or more functions of the proximal gastrointestinal tract. In a randomized controlled, cross-over, single-blinded study, the effects of coffee on gastric relaxation, gastric wall compliance and sensations, elicited by distension, were investigated in 10 healthy volunteers. Using the barostat technique, volume changes of an intragastric bag were recorded for 20 min after intragastric administration of 280 ml of coffee or water. Then, after deflation, the volume of the bag was increased stepwise every 3 min to assess gastric wall compliance and wall tension. At the end of every volume step, sensations (nausea, pain, and bloating) were scored. During the first 20 min after coffee administration, the volume change of the intragastric bag was larger than after water (P < 0.05). There were no differences in gastric wall compliance, wall tension, or symptom scores. In conclusions, coffee, in comparison with water, enhances the adaptive relaxation of the proximal stomach, but has no effect on its wall compliance, wall tension, or sensory function.
P J Boekema; M Samsom; J M Roelofs; A J Smout
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  46     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-08     Completed Date:  2001-05-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  945-51     Citation Subset:  AIM; IM    
Department of Gastroenterology, University Medical Center Utrecht, The Netherlands.
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MeSH Terms
Cross-Over Studies
Middle Aged
Stomach / innervation,  physiology*
Water / pharmacology
Reg. No./Substance:
0/Coffee; 7732-18-5/Water

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