Document Detail

Effect of coenzyme Q10 on the mitochondrial function of skin fibroblasts from Parkinson patients.
MedLine Citation:
PMID:  15140604     Owner:  NLM     Status:  MEDLINE    
Several lines of evidence suggest an impairment of mitochondrial function in the brain of patients with Parkinson's disease (PD). However, the presence of a detectable mitochondrial defect in extracerebral tissue of these patients remains a matter of dispute. Therefore, we investigated mitochondrial function in fibroblasts of 18 PD patients applying biochemical micromethods. Putative beneficial effects of coenzyme Q(10) (CoQ(10)), a potent antioxidant, on the mitochondrial function of skin fibroblast cultures were evaluated. Applying inhibitor titrations of the mitochondrial respiration to calculate flux control coefficients of respiratory chain complexes I and IV, we observed deficiencies of both complexes in cultivated skin fibroblasts of PD patients. Cultivation of fibroblasts in the presence of 5 microM CoQ(10) restored the activity of impaired respiratory chain complexes in the fibroblast cultures of 9 out of 18 PD patients. Our data support the presence of a generalised mitochondrial defect in at least a subgroup of patients with PD that can be partially ameliorated in vitro by coenzyme Q(10) treatment.
Kirstin Winkler-Stuck; Falk R Wiedemann; Claus-W Wallesch; Wolfram S Kunz
Related Documents :
22574854 - Diagnosis and inflammatory response of patients with candiduria.
18688134 - Clinical speech impairment in parkinson's disease, progressive supranuclear palsy, and ...
131644 - Levodopa in huntingtons chorea.
14502664 - Prospective study of presynaptic dopaminergic imaging in patients with mild parkinsonis...
18801674 - Dental and periodontal history of oncologic patients on parenteral bisphosphonates with...
23716414 - Clinco-epidemiologic study of cutaneous leishmaniasis in bikaner, rajasthan, india.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  220     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-13     Completed Date:  2004-07-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  41-8     Citation Subset:  IM    
Klinik für Neurologie der Otto-von-Guericke-Universität Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenosine Diphosphate / pharmacology
Amobarbital / pharmacology
Antioxidants / pharmacology*
Cells, Cultured
Drug Interactions
Fibroblasts / drug effects*
Glutamic Acid / pharmacology
Middle Aged
Mitochondria / drug effects*,  physiology
NAD / pharmacology
Oxygen / metabolism
Parkinson Disease / pathology*
Pyruvic Acid / pharmacology
Skin / pathology*
Ubiquinone / analogs & derivatives*,  pharmacology*
Reg. No./Substance:
0/Antioxidants; 0/Coenzymes; 127-17-3/Pyruvic Acid; 1339-63-5/Ubiquinone; 303-98-0/coenzyme Q10; 53-84-9/NAD; 56-86-0/Glutamic Acid; 57-43-2/Amobarbital; 58-64-0/Adenosine Diphosphate; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Clinical and neuroradiologic features of 39 consecutive cases of West Nile Virus meningoencephalitis...
Next Document:  Dynamic cerebral autoregulation is impaired in glaucoma.