Document Detail


Effect of coenzyme Q10 on the mitochondrial function of skin fibroblasts from Parkinson patients.
MedLine Citation:
PMID:  15140604     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several lines of evidence suggest an impairment of mitochondrial function in the brain of patients with Parkinson's disease (PD). However, the presence of a detectable mitochondrial defect in extracerebral tissue of these patients remains a matter of dispute. Therefore, we investigated mitochondrial function in fibroblasts of 18 PD patients applying biochemical micromethods. Putative beneficial effects of coenzyme Q(10) (CoQ(10)), a potent antioxidant, on the mitochondrial function of skin fibroblast cultures were evaluated. Applying inhibitor titrations of the mitochondrial respiration to calculate flux control coefficients of respiratory chain complexes I and IV, we observed deficiencies of both complexes in cultivated skin fibroblasts of PD patients. Cultivation of fibroblasts in the presence of 5 microM CoQ(10) restored the activity of impaired respiratory chain complexes in the fibroblast cultures of 9 out of 18 PD patients. Our data support the presence of a generalised mitochondrial defect in at least a subgroup of patients with PD that can be partially ameliorated in vitro by coenzyme Q(10) treatment.
Authors:
Kirstin Winkler-Stuck; Falk R Wiedemann; Claus-W Wallesch; Wolfram S Kunz
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  220     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-13     Completed Date:  2004-07-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  41-8     Citation Subset:  IM    
Affiliation:
Klinik für Neurologie der Otto-von-Guericke-Universität Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Diphosphate / pharmacology
Adult
Aged
Amobarbital / pharmacology
Antioxidants / pharmacology*
Cells, Cultured
Coenzymes
Drug Interactions
Female
Fibroblasts / drug effects*
Glutamic Acid / pharmacology
Humans
Male
Middle Aged
Mitochondria / drug effects*,  physiology
NAD / pharmacology
Oxygen / metabolism
Parkinson Disease / pathology*
Pyruvic Acid / pharmacology
Skin / pathology*
Ubiquinone / analogs & derivatives*,  pharmacology*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Coenzymes; 127-17-3/Pyruvic Acid; 1339-63-5/Ubiquinone; 303-98-0/coenzyme Q10; 53-84-9/NAD; 56-86-0/Glutamic Acid; 57-43-2/Amobarbital; 58-64-0/Adenosine Diphosphate; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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