Document Detail

Effect of cocaine on exercise endurance and glycogen use in rats.
MedLine Citation:
PMID:  3372445     Owner:  NLM     Status:  MEDLINE    
To determine the effects of cocaine on exercise endurance, male rats were injected intraperitoneally with cocaine (20 mg/kg body wt) or saline and then run to exhaustion 20 min later at 22 m/min and 15% grade. Saline-injected animals ran 74.9 +/- 16.5 (SD) min, whereas cocaine-treated rats ran only 29 +/- 11.6 min. The drug had no effect on resting blood glucose or lactate levels, nor did it affect resting glycogen levels in liver or red and white vastus muscle. However, it did reduce resting soleus glycogen content by 30%. During exercise liver and soleus glycogen depletion occurred at the same rate in saline- and cocaine-treated animals. In contrast, the rate of glycogen depletion during exercise in red and white vastus was markedly increased in cocaine-treated rats with a corresponding elevation in blood lactate (12 vs. only 5 mM in saline group) at exhaustion. These data suggest that cocaine administration (20 mg/kg) before submaximal exercise dramatically alters glycogen metabolism during exercise, and this effect has a negative impact on exercise endurance.
M E Bracken; D R Bracken; A G Nelson; R K Conlee
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  64     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-06-27     Completed Date:  1988-06-27     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  884-7     Citation Subset:  IM; S    
Exercise Biochemistry Laboratory, Brigham Young University, Provo, Utah 84602.
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MeSH Terms
Blood Glucose / metabolism
Cocaine / pharmacology*
Glycogen / metabolism*
Lactates / blood
Liver Glycogen / metabolism
Muscles / metabolism*
Physical Endurance / drug effects*
Physical Exertion*
Rats, Inbred Strains
Reg. No./Substance:
0/Blood Glucose; 0/Lactates; 0/Liver Glycogen; 50-36-2/Cocaine; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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