| Effect of co-administration of retinoids on rat embryo development in vitro. | |
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MedLine Citation:
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PMID: 12962289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Excess retinyl palmitate (vitamin A) induces a variety of malformations in many mammalian species, yet retinyl palmitate is not thought to be the proximate teratogen. Many metabolites are generated after oral dosing several of which are, individually teratogenic. It is not known whether these metabolites when present simultaneously interact in an additive or synergistic manner. METHODS: Whole rat embryos were cultured with retinol, all-trans retinoic acid (tRA), 4-oxo all-trans retinoic acid (4otRA) or 9-cis retinoic acid (9cRA). Retinoids were added singly or in paired combinations at the start of culture and embryos were examined for evidence of dysmorphogenesis at the end of culture. Retinoids were added at both subthreshold and supra-threshold concentrations. RESULTS: Co-administration of subthreshold concentrations of tRA and 4otRA, retinol and tRA or 4otRA and 4otRA and 9cRA resulted in a greater frequency of abnormal embryos compared to single administration of each retinoid. CONCLUSIONS: Knowledge of the way in which retinyl palmitate metabolites interact should refine our ability to predict risk from a potentially teratogenic event e.g., accidental overdose with RP during human pregnancy. |
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Authors:
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Helen E Ritchie; Patricia D Brown-Woodman; Ann Korabelnikoff |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Birth defects research. Part A, Clinical and molecular teratology Volume: 67 ISSN: 1542-0752 ISO Abbreviation: Birth Defects Res. Part A Clin. Mol. Teratol. Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-09-09 Completed Date: 2004-02-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101155107 Medline TA: Birth Defects Res A Clin Mol Teratol Country: United States |
Other Details:
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Languages: eng Pagination: 444-51 Citation Subset: IM |
Affiliation:
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School of Biomedical Sciences, University of Sydney, Cumberland Campus, Lidcombe, NSW, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced* Animals Dose-Response Relationship, Drug Drug Combinations Embryo, Mammalian / drug effects* Female Organ Culture Techniques Pregnancy Rats Rats, Sprague-Dawley Retinoids / toxicity* Teratogens / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 0/Retinoids; 0/Teratogens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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