Document Detail

Effect of clustering of metabolic syndrome factors on capillary and cerebrovascular impairment.
MedLine Citation:
PMID:  23041467     Owner:  NLM     Status:  Publisher    
BACKGROUND: Hypertension and metabolic disorders, attended by impaired microcirculation, represent major risk factors for cerebrovascular impairment, as well as being individual components of the metabolic syndrome (MetS). Aim of the study was to establish whether mild hypertensives, aged ≤65years, may be affected by progressive microvascular damage impairing cerebrovascular perfusion, related to a progressive clustering of MetS components. METHODS: Twenty-two normotensives with no MetS component (NTN-0), 29 hypertensives with no (HTN-0), 30 with one (HTN-1), 29 with two (HTN-2), 27 with three (HTN-3), 25 with all four (HTN-4) MetS components, were recruited. The study required office and twenty-four hour ambulatory blood pressure monitoring and video capillaroscopy. Functional (fCD), anatomical (aCD) and recruited (RECR) phalangeal skin capillarity were assessed. Cerebral vasodilatory reserve was measured by the breath-holding index (BHI), using transcranial Doppler, in HTN-1 and HTN-2 with MetS. RESULTS: The fCD and aCD were reduced in hypertensives and progressively reduced in those with MetS, while RECR was also impaired. BHI was lower in HTN-2 than in HTN-1 (p<0.001). BHI was correlated with fCD in HTN-1 (.396, p: .046), HNT-2 (.497, p: .011), and with aCD in HTN-2 (.494, p: .012), by partial Pearson test. DISCUSSION: The findings show that hypertensives exhibit an increasing microvascular rarefaction with MetS progression and that an impaired cerebral perfusion occurs when the MetS is established. The data underline the importance of preventing MetS in mild hypertensives, as it causes microvascular damage and impairs cerebral arterial perfusion.
Pietro Nazzaro; Gabriella Schirosi; Domenico Mezzapesa; Marco Petruzzellis; Lucia Pascazio; Gabriella Serio; Lorenzo De Benedittis; Francesco Federico
Related Documents :
7035517 - Flow-dependence of extravascular thermal volume as an index of pulmonary edema.
22063467 - Listeria innocua and aerobic mesophiles during chill storage of inoculated mechanically...
11305737 - Effect of intravenous iloprost and alprostadil (pge1) on peripheral resistance during f...
19036887 - The underwater environment: cardiopulmonary, thermal, and energetic demands.
406277 - Comparison of nitroglycerin-, nitroprusside-, and phentolamine-induced changes in coron...
24470707 - Association between heart rate variability, blood pressure and autonomic activity in cy...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-4
Journal Detail:
Title:  European journal of internal medicine     Volume:  -     ISSN:  1879-0828     ISO Abbreviation:  Eur. J. Intern. Med.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9003220     Medline TA:  Eur J Intern Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.
Department of Neurosciences, Division of Neurology-Stroke Unit, Hypertension, Italy. Electronic address:
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  How many potential drug-drug interactions cause adverse drug reactions in hospitalized patients?
Next Document:  Identification of mitochondria translation elongation factor Tu as a contributor to oxidative damage...