Document Detail

Effect of clozapine on the sleep pattern in the rat.
MedLine Citation:
PMID:  201945     Owner:  NLM     Status:  MEDLINE    
The effect of clozapine on the sleep pattern in the rat was studied after a single injection (2.5--20 mg/kg) and after daily administration for 11 consecutive days (2 X 20 mg/kg/day). After a single injection clozapine significantly suppressed REM sleep in a dose-related way, leaving slow wave sleep (SWS) unchanged. Follwing chronic administration, however, clozapine exerted its most prominent effect on SWS, the enhancement of which persisted for at least 3 days after discontinuation of treatment. REM sleep decreased with the development of tolerance and in the absence of rebound phenomena. The results are discussed in the light of disturbances in brain monoamines and the tolerance these amines developed to repeated administration of clozapine.
E L Spierings; M R Dzoljic; M Godschalk
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology     Volume:  15     ISSN:  0031-7012     ISO Abbreviation:  Pharmacology     Publication Date:  1977  
Date Detail:
Created Date:  1978-02-18     Completed Date:  1978-02-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0152016     Medline TA:  Pharmacology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  551-6     Citation Subset:  IM    
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MeSH Terms
Clozapine / administration & dosage,  pharmacology*
Dibenzazepines / pharmacology*
Dose-Response Relationship, Drug
Sleep / drug effects*
Sleep, REM / drug effects
Time Factors
Reg. No./Substance:
0/Dibenzazepines; 5786-21-0/Clozapine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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