Document Detail

Effect of clonidine premedication on haemodynamic responses to fibreoptic bronchoscopy.
MedLine Citation:
PMID:  10671847     Owner:  NLM     Status:  MEDLINE    
The usual haemodynamic response to fibreoptic bronchoscopy is an increase in heart rate and blood pressure. We therefore compared, in a prospective, randomised, double-blind study, the effect of two doses of oral clonidine premedication (150 microg or 300 microg) with placebo (control group) on the haemodynamic alterations in 62 patients who underwent elective fibreoptic bronchoscopy. Significant increases in blood pressure and heart rate were observed during fibreoptic bronchoscopy only in the control group. Clonidine 150 microg blunted the haemodynamic response to fibreoptic bronchoscopy (p < 0.05). Significant decreases in systolic blood pressure (< 90 mmHg) were observed in all patients premedicated with 300 microg clonidine. Throughout the study nine patients (75%) in the 300 microg clonidine group were treated at least once for hypotension. Compared with the control group, time to awakening was significantly longer only in patients premedicated with 300 microg clonidine. In conclusion, premedication with 150 microg oral clonidine attenuates haemodynamic responses to fibreoptic bronchoscopy, without causing excessive haemodynamic depression and sedation. These data encourage the administration of clonidine as premedication in patients undergoing fibreoptic bronchoscopy, particularly in those with, or at risk for, coronary artery disease.
I Matot; Y Kuras; M R Kramer
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  55     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-03-30     Completed Date:  2000-03-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  269-74     Citation Subset:  AIM; IM    
Department of Anaesthesia and Critical Care Medicine, Hadassah University School of Medicine, Jerusalem, Israel.
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MeSH Terms
Adrenergic alpha-Agonists / pharmacology*
Aged, 80 and over
Blood Pressure / drug effects*,  physiology
Bronchoscopy / adverse effects*
Clonidine / pharmacology*
Double-Blind Method
Heart Rate / drug effects*,  physiology
Middle Aged
Prospective Studies
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 4205-90-7/Clonidine

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