Document Detail

Effect of clonidine on postpartum shivering after epidural analgesia: a randomized, controlled, double-blind study.
MedLine Citation:
PMID:  7963779     Owner:  NLM     Status:  MEDLINE    
In obstetric patients treated with epidural analgesia during labor and delivery, shivering is quite frequent due to stress, vasodilatation, infusion of fluids, low ambient temperature, and the direct effect of solution injected into the epidural space. Sixty obstetric patients who developed shivering after receiving epidural analgesia for delivery were randomly assigned to treatment with clonidine 0.150 mg i.v. (N = 20), meperidine 50 mg i.v. (N = 20), or saline solution (N = 20). Drug administration was double blind. The effect on shivering (graded as all or none), drowsiness, heart rate, and systolic arterial pressure was evaluated 5 min after the study drug was administered. Clonidine was as effective as meperidine in controlling shivering and caused a greater reduction in heart rate. Drowsiness occurred after clonidine as well as meperidine. Thus, clonidine proved to be effective in controlling shivering and adrenergic response after delivery using epidural analgesia and produced an acceptable level of drowsiness.
S Mercadante; P De Michele; G Letterio; A Pignataro; M Sapio; P Villari
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of pain and symptom management     Volume:  9     ISSN:  0885-3924     ISO Abbreviation:  J Pain Symptom Manage     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-11-29     Completed Date:  1994-11-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8605836     Medline TA:  J Pain Symptom Manage     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  294-7     Citation Subset:  IM    
Department of Anesthesia and Intensive Care, Buccheri La Ferla Fatebenefratelli Hospital, Palermo, Italy.
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MeSH Terms
Analgesia, Epidural / adverse effects*
Clonidine / therapeutic use*
Double-Blind Method
Meperidine / therapeutic use
Postpartum Period / physiology*
Shivering / drug effects*
Reg. No./Substance:
4205-90-7/Clonidine; 57-42-1/Meperidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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