Document Detail


Effect of clonidine on excitability and refractoriness of normal cat myocardium.
MedLine Citation:
PMID:  7380588     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Increased activity of sympathetic nervous system enhances cardiac susceptibility to arrhythmias. Clonidine through its central action decrease sympathetic activity to the heart. The aim of this study was to investigate whether Clonidine influences excitability and refractoriness of the heart in such a way that cardiac susceptibility to arrhythmias is reduced. The effect of Clonidine (5 microgram/kg i.v.) on diastolic threshold and refractory period was investigated in the normal cat heart in situ paced at a constant rate. Clonidine increased diastolic threshold up to 63.5 +/- 24.0% (mean +/- SE) of initial value and prolonged refractory period up to 13.2 +/- 2.4% of the control throughout 120 min of observation. These data suggest that Clonidine might be of value as an antiarrhythmic agent in patients with chronic angina in whom ventricular arrhythmias are often associated with excessive sympathetic activity.
Authors:
W Czarnecki; K Herbaczyńska-Cedro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology, therapy, and toxicology     Volume:  18     ISSN:  0174-4879     ISO Abbreviation:  Int J Clin Pharmacol Ther Toxicol     Publication Date:  1980 Apr 
Date Detail:
Created Date:  1980-08-28     Completed Date:  1980-08-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8003415     Medline TA:  Int J Clin Pharmacol Ther Toxicol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  145-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Cats
Clonidine / pharmacology*
Electric Stimulation
Female
Heart / drug effects*
Heart Conduction System / drug effects
Heart Rate / drug effects
Hydrogen-Ion Concentration
Male
Time Factors
Chemical
Reg. No./Substance:
4205-90-7/Clonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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