Document Detail

Effect of clonidine on the circulation and vasoactive hormones after aortic surgery.
MedLine Citation:
PMID:  1997045     Owner:  NLM     Status:  MEDLINE    
After completion of abdominal aortic graft, 29 patients received an i.v. infusion of placebo (n = 16) or clonidine 7 micrograms kg-1 (n = 13) over 120 min in a double-blind study. Cardiovascular variables were measured and plasma samples obtained up to 5 h after arrival in the recovery room, for assay of noradrenaline, adrenaline, vasopressin and renin concentrations. Noradrenaline, adrenaline and vasopressin concentrations decreased in the clonidine group throughout recovery (P less than 0.001, 0.05 and 0.05, respectively, vs placebo). Heart rate was less in the clonidine group (P less than 0.01). There was no significant difference in mean arterial pressure between groups. Stroke volume was larger (P less than 0.01) and there were fewer episodes of hypertension (P less than 0.05) and tachycardia in the clonidine group. In addition, a reduction in the number of circulatory interventions (P less than 0.05) and episodes of shivering was noted in the clonidine group. Mean (SD) postoperative volume requirements were larger in the clonidine group (total postoperative input: clonidine 1462 (604) ml; placebo 1064 (348) ml (P less than 0.05]. These data are consistent with the observation that clonidine modifies endocrine and circulatory status after major surgery.
L Quintin; F Roudot; C Roux; I Macquin; A Basmaciogullari; T Guyene; M Vaubourdolle; J P Viale; F Bonnet; M Ghignone
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  66     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-04-02     Completed Date:  1991-04-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  108-15     Citation Subset:  IM    
Department of Anesthesiology, CHU Mondor, Créteil, France.
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MeSH Terms
Aorta, Abdominal / surgery*
Arginine Vasopressin / blood
Blood Vessel Prosthesis*
Clonidine / administration & dosage,  pharmacology*
Epinephrine / blood
Hemodynamics / drug effects*
Hormones / blood*
Middle Aged
Norepinephrine / blood
Postoperative Period
Renin / blood
Reg. No./Substance:
0/Hormones; 113-79-1/Arginine Vasopressin; 4205-90-7/Clonidine; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; EC

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