Document Detail

Effect of clonidine on the cerebrovascular system in cats.
MedLine Citation:
PMID:  8341034     Owner:  NLM     Status:  MEDLINE    
The effects of clonidine, a potent alpha 2 adrenergic agonist and an imidazole/imidazoline receptor agonist, were examined in the cat cerebrovascular system, measuring cerebral oxygen and carbon dioxide tension (BrPo2, BrPco2) and arterial blood pressure. Intracarotid injection of clonidine (2 micrograms/kg) produced a gradual decrease in systemic blood pressure without initial hypertension, while BrPo2 decreased slightly but significantly. Before and after intracarotid administration of clonidine, cerebrovascular reactivity to carbon dioxide was estimated by changes in BrPo2 and BrPco2 during and after 3 min inhalation of 5% CO2. Clonidine significantly enhanced cerebrovascular reactivity to carbon dioxide. The data suggest that the alpha 2-adrenoceptor and/or imidazoline receptor play an important role in the regulation of cerebral circulation.
Y Izumi; Y Fukuuchi; A Imai; K Isozumi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Keio journal of medicine     Volume:  42     ISSN:  0022-9717     ISO Abbreviation:  Keio J Med     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-09-01     Completed Date:  1993-09-01     Revised Date:  2008-08-07    
Medline Journal Info:
Nlm Unique ID:  0376354     Medline TA:  Keio J Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  64-9     Citation Subset:  IM    
Department of Neurology, School of Medicine, Keio University, Tokyo, Japan.
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MeSH Terms
Blood Pressure / drug effects
Brain / metabolism
Carbon Dioxide / metabolism
Cerebrovascular Circulation / drug effects*
Clonidine / pharmacology*
Oxygen / metabolism
Partial Pressure
Reg. No./Substance:
124-38-9/Carbon Dioxide; 4205-90-7/Clonidine; 7782-44-7/Oxygen

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